Myelofibrosis (MF) is a myeloproliferative disorder that exhibits considerable biological and
clinical heterogeneity. At the two ends of the disease spectrum are the myelodepletive or …

Among hematologic malignancies, the classic Philadelphia-negative chronic
myeloproliferative neoplasms (MPNs) are considered a model of inflammation-related …

Myelofibrosis is a progressive bone marrow malignancy associated with monocytosis, and is
believed to promote the pathological remodelling of the extracellular matrix. Here we show …

Predicting disease progression remains a particularly challenging endeavor in chronic
degenerative disorders and cancer, thus limiting early detection, risk stratification, and …

Proinflammatory signaling is a hallmark feature of human cancer, including in
myeloproliferative neoplasms (MPNs), most notably myelofibrosis (MF). Dysregulated …

Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) have recently been
revealed to be related to chronic inflammation, oxidative stress, and the accumulation of …

Myeloproliferative neoplasms (MPNs), a group of malignant hematological disorders, occur
as a consequence of somatic mutations in the hematopoietic stem cell compartment and …

The last decade has been very important for the quantity of preclinical information obtained
regarding chronic myeloproliferative neoplasms (MPNs) and the following will be dedicated …

Although bone marrow-derived mesenchymal stromal cells (BM-MSCs) have been identified
as a major cellular source of fibrosis, the exact molecular mechanism and signaling …

Aberrant overexpression of Interleukin-8 (IL8) has been reported in Myelodysplastic
Syndromes (MDS), Acute Myeloid Leukemia (AML), Myeloproliferative Neoplasms (MPNs) …