Green fluorescent protein (GFP) from the jellyfish Aequorea victoria and its homologs from
diverse marine animals are widely used as universal genetically encoded fluorescent labels …

Fluorescent probes are one of the cornerstones of real-time imaging of live cells and a
powerful tool for cell biologists. They provide high sensitivity and great versatility while …

The cell-cycle transition from G 1 to S phase has been difficult to visualize. We have
harnessed antiphase oscillating proteins that mark cell-cycle transitions in order to develop …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Although the roots of Ras sprouted from the rich history of retrovirus research, it was the
discovery of mutationally activated RAS genes in human cancer in 1982 that stimulated an …

Toll-like receptors (TLRs) are involved in the recognition of microbial pathogens. A subset of
TLRs, TLR7, TLR8 and TLR9, induces antiviral responses by producing interferon-α (IFN-α) …

Ras signalling has classically been thought to occur exclusively at the inner surface of a
relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact …

Biosensors based on the principle of Förster (or fluorescence) resonance energy transfer
(FRET) have shed new light on the spatiotemporal dynamics of signaling molecules. Among …

Synapse regulation exploits the capacity of actin to function as a stable structural component
or as a dynamic filament. Beyond its well-appreciated role in eliciting visible morphological …

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