Snail1 is the founding member of the Snail superfamily of zinc-finger transcription factors,
which also includes Snail2 (Slug) and Snail3 (Smuc). The superfamily is involved in cell …

Matrix metalloproteinases (MMPs) are a family of nine or more highly homologous Zn++
endopeptidases that collectively cleave most if not all of the constituents of the extracellular …

To identify selective steps in metastasis, those that eliminate nonmetastatic tumor cells more
efficiently than metastatic cells, we have evaluated the sequential dissemination of tumor …

Cytotoxic nucleoside analogues were the first chemotherapeutic agents for cancer
treatment. Cordycepin, an active ingredient of the insect fungus Cordyceps militaris, is a …

The most life-threatening aspects of the oncogenic process are invasion and metastasis.
Even though the clinical significance of such expression of the malignant phenotype has …

Purpose The role of the microenvironment during the initiation and progression of
carcinogenesis is now realized to be of critical importance, both for enhanced understanding …

A group of coordinated cellular processes, not just one gene product, is responsible for
invasion and metastasis, the most life-threatening aspect of cancer. It is now recognized that …

Matrix metalloproteinases (MMPs) are a family of extracellular matrix degrading proteinases.
Owing to their matrix-degrading abilities and high expression in advanced tumors, MMPs …

During progression of an in situ to an invasive cancer, epithelial cells lose expression of
proteins that promote cell–cell contact, and acquire mesenchymal markers, which promote …

Lack of estrogen receptor (ER) and presence of vimentin (VIM) associate with poor
prognosis in human breast cancer. We have explored the relationships between ER, VIM …