Clinical translation of long-acting drug delivery formulations

W Li, J Tang, D Lee, TR Tice… - Nature Reviews …, 2022 - nature.com
Most pharmaceuticals are given using short-acting formulations that require frequent
administration, which can negatively affect patient compliance and increase failure risks …

Polymeric in situ forming depots for long-acting drug delivery systems

AK Pandya, LK Vora, C Umeyor, D Surve… - Advanced Drug Delivery …, 2023 - Elsevier
Polymeric in situ forming depots have emerged as highly promising drug delivery systems
for long-acting applications. Their effectiveness is attributed to essential characteristics such …

In Situ Forming, Enzyme-Responsive Peptoid-Peptide Hydrogels: An Advanced Long-Acting Injectable Drug Delivery System

SM Coulter, S Pentlavalli, Y An, LK Vora… - Journal of the …, 2024 - ACS Publications
Long-acting drug delivery systems are promising platforms to improve patient adherence to
medication by delivering drugs over sustained periods and removing the need for patients to …

[HTML][HTML] Lyotropic liquid crystals for parenteral drug delivery

VP Chavda, S Dawre, A Pandya, LK Vora… - Journal of Controlled …, 2022 - Elsevier
The necessity for long-term treatments of chronic diseases has encouraged the
development of novel long-acting parenteral formulations intending to improve drug …

Clinically established biodegradable long acting injectables: an industry perspective

CI Nkanga, A Fisch, M Rad-Malekshahi… - Advanced drug delivery …, 2020 - Elsevier
Long acting injectable formulations have been developed to sustain the action of drugs in
the body over desired periods of time. These delivery platforms have been utilized for both …

[HTML][HTML] Block copolymer micelles as ocular drug delivery systems

AA Assiri, K Glover, D Mishra, D Waite, LK Vora… - Drug discovery today, 2024 - Elsevier
Highlights•Amphiphilic polymers self-assemble into block copolymer micelles in
solution.•Polymeric micelles have longer and better contact with the ocular …

Thermogels: In situ gelling biomaterial

SS Liow, Q Dou, D Kai, AA Karim, K Zhang… - ACS Biomaterials …, 2016 - ACS Publications
In situ gel delivery systems are preferred over conventional systems due to sustained and
prolonged release action of therapeutic payload onto the targeted site. Thermogel, a form of …

Drug release from in situ forming implants and advances in release testing

X Wang, DJ Burgess - Advanced Drug Delivery Reviews, 2021 - Elsevier
In situ forming implants, defined as liquid formulations that generate solid or semisolid
depots following administration, have shown a range of advantages in drug delivery. This …

Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery

SR Benhabbour, M Kovarova, C Jones… - Nature …, 2019 - nature.com
Here we report an ultra-long-acting tunable, biodegradable, and removable polymer-based
delivery system that offers sustained drug delivery for up to one year for HIV treatment or …

[HTML][HTML] Recent Applications of PLGA in drug delivery systems

J Yang, H Zeng, Y Luo, Y Chen, M Wang, C Wu… - …, 2024 - pmc.ncbi.nlm.nih.gov
Poly (lactic-co-glycolic acid)(PLGA) is a widely used biodegradable and biocompatible
copolymer in drug delivery systems (DDSs). In this article, we highlight the critical …