Carcinomas are complex heterocellular systems containing epithelial cancer cells, stromal
fibroblasts, and multiple immune cell‐types. Cell‐cell communication between these tumor …

Many biological circuits comprise sets of protein variants that interact with one another in a
many-to-many, or promiscuous, fashion. These architectures can provide powerful …

Inferring how gene expression in a cell is influenced by cellular microenvironment is of great
importance yet challenging. In this study, we present a single-cell RNA-sequencing data …

Cardiac glycosides (CGs) are a diverse family of naturally derived compounds having a
steroid and glycone moiety in their structures. CG molecules inhibit the α-subunit of …

The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the
drug discovery process, but it is important in order to rationalise phenotypic findings and to …

The mosquito's innate immune system defends against a variety of pathogens, and the
conserved siRNA pathway plays a central role in the control of viral infections. Here, we …

Ubiquitination is a posttranslational modification of proteins that significantly affects protein
stability and function. The specificity of substrate recognition is determined by ubiquitin E3 …

Abstract Aim Doxorubicin/Cyclophosphamide (AC) is one of the standard adjuvant
anthracycline-containing regimens that is still in use for breast cancer treatment. Cancer cell …

Occurrence and development of cancers are governed by complex networks of interacting
intercellular and intracellular signals. The technology of single-cell RNA sequencing (scRNA …

Honey bees (Apis mellifera) pollinate plants in both natural and managed ecosystems,
contributing to food production and sustaining and increasing biodiversity. Unfortunately bee …