Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease

R Bai, J Guo, XY Ye, Y **e, T **e - Ageing research reviews, 2022 - Elsevier
As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering
to their families and causes a heavy socioeconomic burden to society. A vast amount of …

Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease

M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

[HTML][HTML] Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection

S Shandilya, S Kumar, NK Jha, KK Kesari… - Journal of Advanced …, 2022 - Elsevier
Background Recent research on the implications of gut microbiota on brain functions has
helped to gather important information on the relationship between them. Pathogenesis of …

Targeting free radicals in oxidative stress-related human diseases

P Poprac, K Jomova, M Simunkova, V Kollar… - Trends in …, 2017 - cell.com
Cancer and Alzheimer's disease (AD) are characterized by (i) opposing biological
mechanisms,(ii) an inverse correlation between their incidences, and (iii) oxidative stress …

[HTML][HTML] Lipid peroxidation in cell death

MM Gaschler, BR Stockwell - Biochemical and biophysical research …, 2017 - Elsevier
Disruption of redox homeostasis is a key phenotype of many pathological conditions.
Though multiple oxidizing compounds such as hydrogen peroxide are widely recognized as …

Alzheimer's disease hypothesis and related therapies

X Du, X Wang, M Geng - Translational neurodegeneration, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause for dementia. There are many hypotheses about AD, including abnormal …

Oxidative stress in alzheimer's disease: A review on emergent natural polyphenolic therapeutics

L Cassidy, F Fernandez, JB Johnson, M Naiker… - … therapies in medicine, 2020 - Elsevier
Objectives The aim of this research was to review the literature on Alzheimer's disease (AD)
with a focus on polyphenolics as antioxidant therapeutics. Design This review included a …

Selenium-dependent antioxidant enzymes: Actions and properties of selenoproteins

E Zoidis, I Seremelis, N Kontopoulos, GP Danezis - Antioxidants, 2018 - mdpi.com
Unlike other essential trace elements that interact with proteins in the form of cofactors,
selenium (Se) becomes co-translationally incorporated into the polypeptide chain as part of …

The role of antioxidants in the chemistry of oxidative stress: A review

AM Pisoschi, A Pop - European journal of medicinal chemistry, 2015 - Elsevier
Abstract This Review Article is focused on the action of the reactive oxygenated species in
inducing oxidative injury of the lipid membrane components, as well as on the ability of …

Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies

P Sharma, P Srivastava, A Seth, PN Tripathi… - Progress in …, 2019 - Elsevier
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …