Abstract GH and IGF-I are important regulators of bone homeostasis and are central to the
achievement of normal longitudinal bone growth and bone mass. Although GH may act …

The growth plate is the final target organ for longitudinal growth and results from
chondrocyte proliferation and differentiation. During the first year of life, longitudinal growth …

To examine the relationship between growth hormone (GH) and insulin-like growth factor 1
(IGF1) in controlling postnatal growth, we performed a comparative analysis of dwarfing …

The homodimeric transmembrane receptor natriuretic peptide receptor B (NPR-B [also
known as guanylate cyclase B, GC-B, and GUC2B]; gene name NPR2) produces …

I. Introduction AT THE beginning of this century Aschner (1) demonstrated a relationship
between a factor in the pituitary and body growth. In subsequent experiments Evans and …

Skeletal muscle and bone rely on a number of growth factors to undergo development,
modulate growth, and maintain physiological strength. A major player in these actions is …

Data obtained while investigating growth plate chondrocyte differentiation during
endochondral bone formation both in vivo and in vitro indicate that initial chondrogenesis …

A cDNA encoding the growth hormone (GH) receptor was cloned from rat liver. Both the
nucleotide and translated amino acid sequence share greater than 70% similarity with the …

Linear growth occurs during development and the childhood years until epiphyseal fusion
occurs. This process results from endochondral ossification in the growth plates of long …

Bone serves the triple functions of maintaining the internal structural support for the body,
housing the hematopoeitic system, and providing the reservoir for calcium and phosphate …