Abstract Inositol 1, 4, 5-trisphosphate is a second messenger which regulates intracellular
calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by …

Abstract Knowledge concerning the pathophysiologic mechanisms of traumatic optic
neuropathy is limited. The optic nerve is a tract of the brain. Therefore, the cellular and …

This paper describes the distribution of structures stained with mono-and polyclonal
antibodies to the calcium-binding proteins calbindin D-28k and parvalbumin in the nervous …

1. Whole‐cell patch clamp recordings of membrane currents and fura‐2 measurements of
free intracellular calcium concentration ([Ca2+] i) were used to study the biophysical …

Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein
P 400 Page 1 © 1989 Nature Publishing Group ARTICLES Received 7 April; accepted 5 …

Severe norpA mutations in Drosophila eliminate the photoreceptor potential and render the
fly completely blind. Recent biochemical analyses have shown that norpA mutants lack …

Hepatocytes are well coupled by gap junctions, which allow the diffusion of small molecules
between cells. Although gap junctions in many tissues are permeable to molecules larger …

Introduction Polyamines (putrescine, spermidine and spermine) are ubiquitous polycationic
metabolites in prokaryotic and eukaryotic cells. Their roles in the regulation of major …

Professional phagocytes (neutrophils, eosinophils, monocytes and macrophages) possess
an enzymatic complex, the NADPH oxidase, which is able to catalyze the one‐electron …

In the early 70s, while studying calcium binding proteins of muscle sarcoplasmic reticulum,
MacLennan's group at the University of Toronto identified and characterized several soluble …