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How predictive are isolated perfused liver data of in vivo hepatic clearance? A meta-analysis of isolated perfused rat liver data
JA Schulz Pauly, JC Kalvass - Xenobiotica, 2024 - Taylor & Francis
Isolated perfused rat liver (IPRL) experiments have been used to answer clearance-related
questions, including evaluating the impact of pathological and physiological processes on …
questions, including evaluating the impact of pathological and physiological processes on …
Clearance prediction with three novel plated human hepatocyte models compared to conventional suspension assays: Assessment with 50 compounds and multiple …
DA Kukla, JAS Pauly, PR Lesniak, E Sande… - Drug Metabolism and …, 2025 - Elsevier
Incubation of drugs with suspension hepatocytes (SH) to determine intrinsic clearance is
common in drug discovery. However, the limited duration of SH assays hampers clearance …
common in drug discovery. However, the limited duration of SH assays hampers clearance …