Lately, scandals associated with the illegal addition of poisonous chemicals to food for
commercial interests have been gradually disclosed to the public. Problems related to food …

In this work, we developed a microfluidic device for the imitation of drug metabolism in
human liver and its cytotoxicity on cells. The integrated microfluidic device consists of three …

New chemicals or drugs must be guaranteed safe before they can be marketed. Despite
widespread use of bioassay panels for toxicity prediction, products that are toxic to a subset …

Since bacterial consortia involved in conventional wastewater treatment processes are not
efficient in removing diclofenac (DCF), an emerging pollutant frequently detected in water …

A high throughput electrochemiluminescent (ECL) chip was fabricated and integrated into a
fluidic system for screening toxicity-related chemistry of drug and pollutant metabolites. The …

Routine in vitro bioassays and animal toxicity studies of drug and environmental chemical
candidates fail to reveal toxicity in∼ 30% of cases. This Feature article addresses research …

A novel, simple, rapid microfluidic array using bioelectronically driven cytochrome P450
enzyme catalysis for reactive metabolite screening is reported for the first time. The device …

Human liver subcellular fractions, including liver microsomes (HLM), liver cytosol fractions,
and S9 fractions, are extensively utilized in in vitro assays to predict liver metabolism. The …

The increasing demand to monitor multiple classes of analytes has been mirrored by
increased analytical cost and decreased throughput. For instance, the analyses of estrogens …

Complex functional films containing enzymes and other biomolecules are easily fabricated
in nm-scale thicknesses by using layer-by-layer (LbL) methodologies first popularized by …