Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-
soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic …

CYP17A1 is an enzyme that plays a major role in steroidogenesis and is critically involved in
the biosynthesis of steroid hormones. Therefore, it remains an attractive target in several …

Enzymes are complex biological catalysts and are critical to life. Most oxidations of
chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which generally utilize …

Abstract Cytochrome P450 17A1 (CYP17A1) is a critical steroidogenic enzyme, essential for
producing glucocorticoids and sex hormones. This review discusses the complex activity of …

The human cytochrome P450 17A1 (CYP17A1) enzyme operates at a key juncture of human
steroidogenesis, controlling the levels of mineralocorticoids influencing blood pressure …

Progesterone receptor membrane component 1 (PGRMC1) is a heme-binding protein
implicated in a wide range of cellular functions. We previously showed that PGRMC1 binds …

The cytochrome P450 monooxygenases (P450s) are thiolate heme proteins that can, often
under physiological conditions, catalyze many distinct oxidative transformations on a wide …

Cytochrome P450 (P450) enzymes are major catalysts involved in the oxidations of most
drugs, steroids, carcinogens, fat-soluble vitamins, and natural products. The binding of …

Benzo [a] pyrene (BaP) is a human carcinogen that covalently binds to DNA after metabolic
activation by cytochrome P450 (CYP) enzymes. In this study human recombinant CYPs …

Through their unique oxidative chemistry, cytochrome P450 monooxygenases (CYPs)
catalyze the elimination of most drugs and toxins from the human body. Protein–protein …