The fascination and fear of snakes dates back to time immemorial, with the first scientific
treatise on snakebite envenoming, the Brooklyn Medical Papyrus, dating from ancient Egypt …

Venom (toxins) is an important trait evolved along the evolutionary tree of animals. Our
knowledges on venoms, such as their origins and loss, the biological relevance and the …

Abstract The epithelial Na+ channel (ENaC) and the acid-sensing ion channels (ASICs) form
subfamilies within the ENaC/degenerin family of Na+ channels. ENaC mediates …

Acid‐sensing ion channels (ASICs) and the epithelial Na+ channel (ENaC) are both
members of the ENaC/degenerin family of amiloride‐sensitive Na+ channels. ASICs act as …

Snake venoms are complex mixtures of small molecules and peptides/proteins, and most of
them display certain kinds of bioactivities. They include neurotoxic, cytotoxic, cardiotoxic …

Ion channels are vital contributors to cellular communication in a wide range of organisms, a
distinct feature that renders this ubiquitous family of membrane-spanning proteins a prime …

Abstract Development of the pharmacology of Acid-Sensing Ion Channels (ASICs) has
become a key challenge to study their structure, their molecular and cellular functions and …

Temple-Baraitser syndrome (TBS) is a multisystem developmental disorder characterized by
intellectual disability, epilepsy, and hypoplasia or aplasia of the nails of the thumb and great …

Animal venoms are complex mixtures containing peptides and proteins known as toxins,
which are responsible for the deleterious effect of envenomations. Across the animal …

Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic
acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …