Neuroinflammation plays a pivotal role in Alzheimer's disease (AD) and Parkinson's disease
(PD), the leading causes of dementia. These neurological disorders are characterized by the …

Over 30 million people suffer from the consequences of ischemic stroke. The precise
molecular mechanism of neuronal damage during ischemic stroke remains unclear; …

Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …

Oxidative damage to DNA has important implications for human health and has been
identified as a key factor in the onset and development of numerous diseases. Thus, it is …

Melatonin, or 5-methoxy-N-acetyltryptamine, is synthesized and released by the pineal
gland and locally in the retina following a circadian rhythm, with low levels during the day …

Melatonin, N‐acetyl‐5‐methoxytryptamine, an evolutionally old molecule, is produced by the
pineal gland in vertebrates, and it binds with high affinity to melatonin receptors, which are …

Melatonin has demonstrated a potential protective effect in central nervous system. Thus, it
is interesting to determine whether pre‐ischemia melatonin administration could protect …

Nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central
nervous system, being expressed in neurons and non-neuronal cells, where they participate …

Abstract Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master regulator of cellular
homeostasis that controls the expression of more than 1% of human genes related to …

Stroke is one of the leading causes of death and disability in the world. Oxidative stress,
which refers to an excessive generation of reactive oxygen species (ROS), plays a key role …