A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery
The upward extend of malaria collectively with the emergence of resistance against
predictable drugs has put enormous pressure on public health systems to introduce new …
predictable drugs has put enormous pressure on public health systems to introduce new …
Quinoline drug–heme interactions and implications for antimalarial cytostatic versus cytocidal activities
Historically, the most successful molecular target for antimalarial drugs has been heme
biomineralization within the malarial parasite digestive vacuole. Heme released from …
biomineralization within the malarial parasite digestive vacuole. Heme released from …
Identification of a novel binding mechanism of Quinoline based molecules with lactate dehydrogenase of Plasmodium falciparum
The deadliest disease caused by the Plasmodium species is malaria. Among other species,
the infection caused by Plasmodium falciparum (Pf) is life-threatening. The biological …
the infection caused by Plasmodium falciparum (Pf) is life-threatening. The biological …
Antimalarial drugs inhibiting hemozoin (β-hematin) formation: a mechanistic update
Digestion of hemoglobin in the food vacuole of the malaria parasite produces very high
quantities of redox active toxic free heme. Hemozoin (β-hematin) formation is a unique …
quantities of redox active toxic free heme. Hemozoin (β-hematin) formation is a unique …
The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization
The intraerythrocytic malaria parasite constructs an intracellular haem crystal, called
haemozoin, within an acidic digestive vacuole where haemoglobin is degraded. Haem …
haemozoin, within an acidic digestive vacuole where haemoglobin is degraded. Haem …
“Recycling” classical drugs for malaria
Malaria has been a human health concern ever since the dawn of mankind, but despite the
huge struggles made to date to fight this infection, in 2012 over half a million people were …
huge struggles made to date to fight this infection, in 2012 over half a million people were …
Antimalarials inhibit hematin crystallization by unique drug–surface site interactions
In malaria pathophysiology, divergent hypotheses on the inhibition of hematin crystallization
posit that drugs act either by the sequestration of soluble hematin or their interaction with …
posit that drugs act either by the sequestration of soluble hematin or their interaction with …
Antimalarial Activity of Potential Inhibitors of Plasmodium falciparum Lactate Dehydrogenase Enzyme Selected by Docking Studies
J Penna-Coutinho, WA Cortopassi, AA Oliveira… - PloS one, 2011 - journals.plos.org
The Plasmodium falciparum lactate dehydrogenase enzyme (Pf LDH) has been considered
as a potential molecular target for antimalarials due to this parasite's dependence on …
as a potential molecular target for antimalarials due to this parasite's dependence on …
Recent developments in the design and synthesis of hybrid molecules basedon aminoquinoline ring and their antiplasmodial evaluation
A short history of hybrid molecules based on aminoquinolines gave interesting and
important information useful for organic and medicinal chemistry, which are deeply involved …
important information useful for organic and medicinal chemistry, which are deeply involved …
Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial, cytotoxic and antitubercular agents
J Camacho, A Barazarte, N Gamboa… - Bioorganic & medicinal …, 2011 - Elsevier
A series of N′-substituted-2-(5-nitrofuran or 5-nitrothiophen-2-yl)-3H-benzo [d] imidazole-5-
carbohydrazide derivatives were synthesized and investigated for their abilities to inhibit β …
carbohydrazide derivatives were synthesized and investigated for their abilities to inhibit β …