Mechanism of action of ribosomally synthesized and post-translationally modified peptides

C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022‏ - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

The microbiome-sha** roles of bacteriocins

S Heilbronner, B Krismer, H Brötz-Oesterhelt… - Nature Reviews …, 2021‏ - nature.com
The microbiomes on human body surfaces affect health in multiple ways. They include not
only commensal or mutualistic bacteria but also potentially pathogenic bacteria, which can …

Genomics and pathotypes of the many faces of Escherichia coli

J Geurtsen, M de Been, E Weerdenburg… - FEMS microbiology …, 2022‏ - academic.oup.com
Escherichia coli is the most researched microbial organism in the world. Its varied impact on
human health, consisting of commensalism, gastrointestinal disease, or extraintestinal …

Bacteriocins, potent antimicrobial peptides and the fight against multi drug resistant species: resistance is futile?

E Meade, MA Slattery, M Garvey - Antibiotics, 2020‏ - mdpi.com
Despite highly specialized international interventions and policies in place today, the rapid
emergence and dissemination of resistant bacterial species continue to occur globally …

Genetic innovations in animal–microbe symbioses

J Perreau, NA Moran - Nature Reviews Genetics, 2022‏ - nature.com
Animal hosts have initiated myriad symbiotic associations with microorganisms and often
have maintained these symbioses for millions of years, spanning drastic changes in …

Evolutionary pathways and trajectories in antibiotic resistance

F Baquero, JL Martinez, V F. Lanza… - Clinical Microbiology …, 2021‏ - Am Soc Microbiol
Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …

Advanced delivery systems for peptide antibiotics

A Cesaro, S Lin, N Pardi… - Advanced drug delivery …, 2023‏ - Elsevier
Antimicrobial peptides (AMPs) hold promise as alternatives to traditional antibiotics for
preventing and treating multidrug-resistant infections. Although they have potent …

Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics

JP Lynch, L Goers, CF Lesser - Trends in pharmacological sciences, 2022‏ - cell.com
Engineered microbes are rapidly being developed for the delivery of therapeutic modalities
to sites of disease. Escherichia coli Nissle 1917 (EcN), a genetically tractable probiotic with …

Promising therapeutic strategies against microbial biofilm challenges

K Zhang, X Li, C Yu, Y Wang - Frontiers in Cellular and Infection …, 2020‏ - frontiersin.org
Biofilms are communities of microorganisms that are attached to a biological or abiotic
surface and are surrounded by a self-produced extracellular matrix. Cells within a biofilm …

Translating eco-evolutionary biology into therapy to tackle antibiotic resistance

F Sanz-García, T Gil-Gil, P Laborda, P Blanco… - Nature Reviews …, 2023‏ - nature.com
Antibiotic resistance is currently one of the most important public health problems. The
golden age of antibiotic discovery ended decades ago, and new approaches are urgently …