Nowadays, dipeptidyl peptidase-IV (DPP-IV) is emerging as a hopeful drug target for treating
Type 2 diabetic mellitus (T2DM). Currently marketed DPP-IV inhibitors work by lowering the …

Quinazoline derivatives, as an important category of heterocyclic compounds, have received
much attention for the design and development of new drugs due to their various …

Cancer is a disease characterized by genetic or epigenetic alterations in somatic cells that
result in uncontrolled cell growth and spread to other regions of the body. They are one type …

Fungal infections are still threatening human health due to resistance to existing drugs,
therefore, the design and development of novel antifungal agents is to be necessary and …

A series of quinazolinone derivatives (7a–7h) were synthesized as antiproliferative agents.
All compounds, were synthesized through three steps method and structurally evaluated by …

Several diabetic complications are associated with forming advanced glycation end
products (AGEs). Different chemical and natural compounds are able to prevent the …

A novel series of 4-aminopiperidin-3, 4-dihyroquinazoline-2-uracil derivatives (9a-9 L) were
logically designed and synthesized as potent DPP4 inhibitors as antidiabetic agents …

Based on unselectively, several side effects and drug resistance of available anticancer
agents, the development and research for novel anticancer agents is necessary. In this …

A novel series of quinazoline-pyrimidine derivatives (3a-3i) linked to different aryl
substitutions were designed and synthesized as promising anti-cancer candidates. The …

Bioassay-guided fractionation of a dichloromethane extract of the aerial parts of Salvia
urmiensis, an endemic plant species of Iran, led to the isolation of two new cytotoxic ursane …