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Recent developments of transition-state analogue glycosidase inhibitors of non-natural product origin
Glycosidase inhibitors have been subject to extensive interest in the past decade. As
glycoside cleavage is a biologically widespread process, glycosidase inhibitors have many …
glycoside cleavage is a biologically widespread process, glycosidase inhibitors have many …
Glycosidase mechanisms
The three-dimensional structure of glycosidases and of their complexes and the study of
transition-state mimics reveal structural details that correlate with mechanism. Of particular …
transition-state mimics reveal structural details that correlate with mechanism. Of particular …
Catalytic mechanism of enzymic glycosyl transfer
ML Sinnott - Chemical Reviews, 1990 - ACS Publications
At least in terms of simple tonnage, glycosyl transfer must be accounted one of the most
important biochemical reactions, since around two-thirds of the carbon in the biosphere …
important biochemical reactions, since around two-thirds of the carbon in the biosphere …
Stereochemistry of nucleophilic substitution reactions depending upon substituent: evidence for electrostatic stabilization of pseudoaxial conformers of oxocarbenium …
L Ayala, CG Lucero, JAC Romero… - Journal of the …, 2003 - ACS Publications
Lewis acid-mediated nucleophilic substitution reactions of substituted tetrahydropyran
acetates reveal that the conformational preferences of six-membered-ring cations depend …
acetates reveal that the conformational preferences of six-membered-ring cations depend …
Toward a Detailed Understanding of Base Excision Repair Enzymes: Transition State and Mechanistic Analyses of N-Glycoside Hydrolysis and N-Glycoside …
This review focuses on the chemistry performed by base excision repair (BER) enzymes,
enzymes that remove nucleobases from DNA in the first step of the repair of many types of …
enzymes that remove nucleobases from DNA in the first step of the repair of many types of …
Stereochemical reversal of nucleophilic substitution reactions depending upon substituent: reactions of heteroatom-substituted six-membered-ring oxocarbenium ions …
JAC Romero, SA Tabacco… - Journal of the American …, 2000 - ACS Publications
Although conformational preferences of neutral six-memberedring systems are dominated
by steric effects, 1 recent computational studies suggest that electronic effects exert a …
by steric effects, 1 recent computational studies suggest that electronic effects exert a …
Synthesis and biological activity of natural aminocyclopentitol glycosidase inhibitors: mannostatins, trehazolin, allosamidins, and their analogues
A Berecibar, C Grandjean… - Chemical …, 1999 - pubmed.ncbi.nlm.nih.gov
Synthesis and Biological Activity of Natural Aminocyclopentitol Glycosidase Inhibitors:
Mannostatins, Trehazolin, Allosamidins, and Their Analogues Synthesis and Biological …
Mannostatins, Trehazolin, Allosamidins, and Their Analogues Synthesis and Biological …
Antiviral therapy for human immunodeficiency virus infections
E De Clercq - Clinical microbiology reviews, 1995 - journals.asm.org
Depending on the stage of their intervention with the viral replicative cycle, human
immunodeficiency virus inhibitors could be divided into the following groups:(i) adsorption …
immunodeficiency virus inhibitors could be divided into the following groups:(i) adsorption …
[ספר][B] C-Glycoside synthesis
M Postema - 2020 - taylorfrancis.com
This book examines methods particularly well suited for either a-or bC-glycoside formation. It
helps field workers quickly select the best method for synthesizing a particular type of C …
helps field workers quickly select the best method for synthesizing a particular type of C …
Enzyme-catalyzed aldol condensation for asymmetric synthesis of azasugars: synthesis, evaluation, and modeling of glycosidase inhibitors
T Kajimoto, KKC Liu, RL Pederson… - Journal of the …, 1991 - ACS Publications
A combined fructose 1, 6-diphosphate aldolase reaction and catalytic reductive animation
has been used in the asymmetric synthesis of azasugars structurally correspondingto 7V …
has been used in the asymmetric synthesis of azasugars structurally correspondingto 7V …