Constitutive heterochromatin is a major component of the eukaryotic nucleus and is
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …

DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

Mitotic cell division increases tumour mutation burden and copy number load, predictive
markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic …

This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …

Widespread changes to DNA methylation and chromatin are well documented in cancer, but
the fate of higher-order chromosomal structure remains obscure. Here we integrated …

During the progression of pancreatic ductal adenocarcinoma (PDAC), heterogeneous
subclonal populations emerge that drive primary tumor growth, regional spread, distant …

Epigenetic clocks, developed using DNA methylation data, have been widely used to
quantify biological aging in multiple tissues/cells. However, many existing epigenetic clocks …

DNA methylation loss occurs frequently in cancer genomes, primarily within lamina-
associated, late-replicating regions termed partially methylated domains (PMDs). We …

Background Intra-sample cellular heterogeneity presents numerous challenges to the
identification of biomarkers in large Epigenome-Wide Association Studies (EWAS). While a …

DNA methylation (DNAm) is important in brain development and is potentially important in
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …