The traditional healthcare system is at the doorstep for entering into the arena of molecular
medicine. The enormous knowledge and ongoing research have now been able to …

Genome editing took a dramatic turn with the development of the clustered regularly
interspaced short palindromic repeats (CRISPR)-CRISPR-associated proteins (Cas) system …

The combined availability of whole genome sequences and genome editing tools is set to
revolutionize the field of fruit biotechnology by enabling the introduction of targeted genetic …

To the Editor: CRISPR–Cas9 editing shows promise for correcting disease-causing
mutations. For example, in a recent study we used CRISPR-Cas9 for sight restoration in …

Genome engineering with programmable nucleases depends on cellular responses to a
targeted double-strand break (DSB). The first truly targetable reagents were the zinc finger …

Advances in the development of delivery, repair, and specificity strategies for the CRISPR-
Cas9 genome engineering toolbox are hel** researchers understand gene function with …

Crossbreeding, mutation breeding, and traditional transgenic breeding take much time to
improve desirable characters/traits. CRISPR/Cas-mediated genome editing (GE) is a game …

Genome-editing technologies based on programmable nucleases have significantly
broadened our ability to make precise and direct changes in the genomic DNA of various …

RNA-guided nucleases (RGNs) based on the type II CRISPR-Cas9 system of Streptococcus
pyogenes (Sp) have been widely used for genome editing in experimental models …

Hemophilia A is an X-linked genetic disorder caused by mutations in the F8 gene, which
encodes the blood coagulation factor VIII. Almost half of all severe hemophilia A cases result …