Objective: To review the literature on the role of autoimmunity in the etiology of
endometriosis, compare the similarities in the pathophysiologies between endometriosis …

Standard of care for ulcerative colitis involves long‐term pharmacotherapy or colectomy.
Approximately 20% to 30% of patients eventually require a colectomy because patients …

Normal individuals maintain tolerance to the endogenous bacterial flora residing within their
alimentary tract, a phenomenon mediated by the gastrointestinal lymphoid tissue. Loss of …

With recent advances in the understanding of its pathophysiology, inflammatory bowel
disease has become a very active area for the development of novel therapeutic agents …

Cyclic nucleotides (cAMP, cGMP) play a major role in normal and pathologic signaling.
Beyond receptors, cyclic nucleotide phosphodiesterases;(PDEs) rapidly convert the cyclic …

Chitinases belong to the evolutionarily conserved glycosyl hydrolase family 18 (GH18). They
catalyze degradation of chitin to N-acetylglucosamine by hydrolysis of the β-(1-4)-glycosidic …

Over the past few years, many observations of overwhelming post splenectomy bacterial
infections have been reported. Streptococcus pneumoniae is the aetiologic agent in about …

Suppression of tumour necrosis factor alpha (TNF-α) and other interleukins by wormwood
(Artemisia absinthium) extracts were reported recently in in vitro studies. The aim of the …

Background and aims: To verify whether targeting defective mucosal T cell death underlies
the sustained therapeutic benefit of infliximab in Crohn's disease, we explored its in vivo …

Background: Thalidomide improves clinical symptoms in patients with therapy refractory
Crohn's disease, as shown in two recent studies. The mechanism of this effect however is …