Rhythmicity is a universal timing mechanism in the brain, and the rhythmogenic mechanisms
are generally dynamic. This is illustrated for the neuronal control of breathing, a behavior …

Breathing in mammals is a seemingly straightforward behaviour controlled by the brain. A
brainstem nucleus called the preBötzinger Complex sits at the core of the neural circuit …

Insults to the develo** cerebellum can cause motor, language, and social deficits. Here,
we investigate whether developmental insults to different cerebellar neurons constrain the …

Contiguous brain regions associated with a given behavior are increasingly being divided
into subregions associated with distinct aspects of that behavior. Using recently developed …

Maintaining constant CO2 and H+ concentrations in the arterial blood is critical for life. The
principal mechanism through which this is achieved in mammals is the respiratory …

The ongoing process of breathing underlies the gas exchange essential for mammalian life.
Each respiratory cycle ensues from the activity of rhythmic neural circuits in the brainstem …

Key points This study explores the state dependence of the hypercapnic ventilatory reflex
(HCVR). We simulated an instantaneous increase or decrease of central chemoreceptor …

Breathing in mammals is hypothesized to result from the interaction of two distinct oscillators:
the preBötzinger Complex (preBötC) driving inspiration and the lateral parafacial region …

All behaviors require coordinated activation of motoneurons from central command and
premotor networks. The genetic identities of premotoneurons providing behaviorally relevant …

The rostroventrolateral medulla contains two functional neuronal populations:(1) the
parafacial respiratory group (pFRG) neurons and (2) the chemosensitive retrotrapezoid …