Growing evidence from cerebrospinal fluid samples and post-mortem brain tissue from
individuals with multiple sclerosis (MS) and rodent models indicates that the meninges have …

The emergence of complement as an important player in normal brain development and
pathological remodelling has come as a major surprise to most scientists working in …

Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by
massive infiltration of immune cells, demyelination, and axonal loss. Active MS lesions …

Objective Cortical gray matter (GM) pathology, involving demyelination and
neurodegeneration, associated with meningeal inflammation, could be important in …

Oligodendrocyte progenitor cells (OPCs) account for approximately 5% of the adult brain
and have been historically studied for their role in myelination. In the adult brain, OPCs …

C1q is a crucial component of the complement system, which is activated through the
classical pathway to perform non-specific immune functions, serving as the first line of …

The last 15 years have seen an explosion of new findings on the role of complement, a
major arm of the immune system, in the central nervous system (CNS) compartment …

The complement system has been involved in the pathogenesis of multiple
neuroinflammatory and neurodegenerative conditions. In this review, we evaluated the …

Even though several highly effective treatments have been developed for multiple sclerosis
(MS), the underlying pathological mechanisms and drivers of the disease have not been …

The human body has biological redox systems capable of preventing or mitigating the
damage caused by increased oxidative stress throughout life. One of them are the …