Mitochondria are highly dynamic organelles that participate in ATP generation and involve
calcium homeostasis, oxidative stress response, and apoptosis. Dysfunctional or damaged …

Myocardial ischemia is a disease with high morbidity and mortality, for which reperfusion is
currently the standard intervention. However, the reperfusion may lead to further myocardial …

The 30-year anniversary of the discovery of'ischaemic preconditioning'is in 2016. This
endogenous phenomenon can paradoxically protect the heart from acute myocardial …

To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers
in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the …

Despite prompt reperfusion by primary percutaneous coronary intervention (PPCI), the
mortality and morbidity of patients presenting with an acute ST-segment elevation …

Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Remote ischaemic conditioning (RIC) triggers endogenous protective pathways in distant
organs such as the kidney, heart and brain, and represents an exciting new paradigm in …

Ferroptosis, a form of regulated cell death, plays an important role in acute kidney injury
(AKI). Previous studies have shown that prolyl hydroxylase domain protein (PHD) inhibitors …

During cardiac reperfusion after myocardial infarction, the heart is subjected to cascading
cycles of ischaemia reperfusion injury (IRI). Patients presenting with this injury succumb to …

Mitochondria alter their shape by undergoing cycles of fusion and fission. Changes in
mitochondrial morphology impact on the cellular response to stress, and their interactions …