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Bacterial persisters: molecular mechanisms and therapeutic development
H Niu, J Gu, Y Zhang - Signal transduction and targeted therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …
bacteria that survive in stress environments such as antibiotic exposure, acidic and …
Formation, physiology, ecology, evolution and clinical importance of bacterial persisters
Persisters are transiently tolerant variants that allow populations to avoid eradication by
antibiotic treatment. Their antibiotic tolerance is non-genetic, not inheritable and results from …
antibiotic treatment. Their antibiotic tolerance is non-genetic, not inheritable and results from …
Persister formation in Staphylococcus aureus is associated with ATP depletion
Persisters are dormant phenotypic variants of bacterial cells that are tolerant to killing by
antibiotics 1. Persisters are associated with chronic infections and antibiotic treatment failure …
antibiotics 1. Persisters are associated with chronic infections and antibiotic treatment failure …
[HTML][HTML] Molecular mechanisms underlying bacterial persisters
E Maisonneuve, K Gerdes - Cell, 2014 - cell.com
All bacteria form persisters, cells that are multidrug tolerant and therefore able to survive
antibiotic treatment. Due to the low frequencies of persisters in growing bacterial cultures …
antibiotic treatment. Due to the low frequencies of persisters in growing bacterial cultures …
Activated ClpP kills persisters and eradicates a chronic biofilm infection
Chronic infections are difficult to treat with antibiotics but are caused primarily by drug-
sensitive pathogens. Dormant persister cells that are tolerant to killing by antibiotics are …
sensitive pathogens. Dormant persister cells that are tolerant to killing by antibiotics are …
Persister cells
K Lewis - Annual review of microbiology, 2010 - annualreviews.org
Persisters are dormant variants of regular cells that form stochastically in microbial
populations and are highly tolerant to antibiotics. High persister (hip) mutants of …
populations and are highly tolerant to antibiotics. High persister (hip) mutants of …
Physiological heterogeneity in biofilms
Biofilms contain bacterial cells that are in a wide range of physiological states. Within a
biofilm population, cells with diverse genotypes and phenotypes that express distinct …
biofilm population, cells with diverse genotypes and phenotypes that express distinct …
Persister cells, dormancy and infectious disease
K Lewis - Nature Reviews Microbiology, 2007 - nature.com
Several well-recognized puzzles in microbiology have remained unsolved for decades.
These include latent bacterial infections, unculturable microorganisms, persister cells and …
These include latent bacterial infections, unculturable microorganisms, persister cells and …
Emergence of Pseudomonas aeruginosa Strains Producing High Levels of Persister Cells in Patients with Cystic Fibrosis
LR Mulcahy, JL Burns, S Lory, K Lewis - Journal of bacteriology, 2010 - journals.asm.org
The majority of cystic fibrosis (CF) patients succumb to a chronic infection of the airway with
Pseudomonas aeruginosa. Paradoxically, pathogenic strains are often susceptible to …
Pseudomonas aeruginosa. Paradoxically, pathogenic strains are often susceptible to …
Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli
Bacteria induce stress responses that protect the cell from lethal factors such as DNA-
damaging agents. Bacterial populations also form persisters, dormant cells that are highly …
damaging agents. Bacterial populations also form persisters, dormant cells that are highly …