The pathologic paradigm for renal progression is advancing tubulointerstitial fibrosis.
Whereas mechanisms underlying fibrogenesis have grown in scope and understanding in …

Arthrofibrosis is a fibrotic joint disorder that begins with an inflammatory reaction to insults
such as injury, surgery and infection. Excessive extracellular matrix and adhesions contract …

Medical devices and implants made of synthetic materials can induce an immune-mediated
process when implanted in the body called the foreign body response, which results in …

TGF-β1 signaling is a critical driver of collagen accumulation and fibrotic disease but also a
vital suppressor of inflammation and epithelial cell proliferation. The nature of this …

Fibrosis is a severe health problem characterized by progressive stiffening of tissues which
causes organ malfunction and failure. A major bottleneck in develo** new anti-fibrosis …

Glioblastoma is a highly vascularized brain tumor, and antiangiogenic therapy improves its
progression-free survival. However, current antiangiogenic therapy induces serious adverse …

Fibrosis, seen in the liver, lung, heart, kidney, and skin, is a significant global disease
burden. Currently, therapeutic treatment is limited, and the number of cases continues to …

Nonalcoholic fatty liver disease (NAFLD), the most common liver disease, has become a
silent worldwide pandemic. The incidence of NAFLD correlates with the rise in obesity, type …

Increased vascular permeability contributes to many diseases, including acute respiratory
distress syndrome, cancer and inflammation. Most past work on vascular barrier function has …

Introduction Although stem cell therapy is a promising treatment for myocardial infarction, the
minimal functional improvements observed clinically limit its widespread application. A need …