Recent developments in synthetic α-glucosidase inhibitors: A comprehensive review with structural and molecular insight

A Singh, K Singh, A Sharma, K Kaur, K Kaur… - Journal of Molecular …, 2023 - Elsevier
Diabetes mellitus is the prominent metabolic disorder affecting 422 million people around
the globe and cause severe associated problems like kidney disorders, heart and nervous …

Recent insights about pyrrolidine core skeletons in pharmacology

S Poyraz, HA Döndaş, NY Döndaş… - Frontiers in …, 2023 - frontiersin.org
To overcome numerous health disorders, heterocyclic structures of synthetic or natural origin
are utilized, and notably, the emergence of various side effects of existing drugs used for …

Sonochemical synthesis of New Thiazolidin-4-one derivatives as potent anticancer and antimicrobial agents with Docking design, and Energy gap estimation

SA Hassan, JB Ziwar, D muhammed Aziz… - Journal of Molecular …, 2024 - Elsevier
Thiazolidin-4-ones have important biological features, which has led to the development of
new derivatives employing an efficient ultrasonic method. Schiff base derivatives were …

[HTML][HTML] Design, synthesis and bioevaluation of new vanillin hybrid as multitarget inhibitor of α-glucosidase, α-amylase, PTP-1B and DPP4 for the treatment of type-II …

MA Huneif, DB Alshehri, KS Alshaibari… - Biomedicine & …, 2022 - Elsevier
Diabetes mellitus (DM) is a real challenge to the recent era and is one of the major diseases
for initiating life-threatening disorders. In current research, a compound was designed by …

Interfacial phenomena and surface protection of N80-carbon steel in acidic environments using thiazolidinediones: an experimental and computational analysis

AA Mansour, C Hejjaj, FZ Thari, K Karrouchi… - Colloids and Surfaces A …, 2023 - Elsevier
In petrochemical engineering, a pressing challenge is the corrosion of N80 carbon steel
(N80-CS) in strong acidic conditions like 15 wt% HCl, impacting both mechanical integrity …

Recent advances of α-glucosidase inhibitors: a comprehensive review

N Agrawal, M Sharma, S Singh… - Current topics in …, 2022 - benthamdirect.com
Background: Diabetes mellitus (DM) is a critical health issue prevailing in nearly half a
billion people worldwide. It is one of the most threatening metabolic diseases. Type 2 DM is …

SAR and lead optimization of (Z)-5-(4-hydroxy-3-methoxybenzylidene)-3-(2-morpholinoacetyl) thiazolidine-2, 4-dione as a potential multi-target antidiabetic agent

M Shah, MS Jan, A Sadiq, S Khan, U Rashid - European Journal of …, 2023 - Elsevier
In case of metabolic disorder like Diabetes mellitus (DM), a number of key enzymes are
abnormally expressed and hence they might be excellent targets for antidiabetic drug …

Research progress in biological activities of succinimide derivatives

Z Zhao, J Yue, X Ji, M Nian, K Kang, H Qiao… - Bioorganic …, 2021 - Elsevier
Succinimides are well recognized heterocyclic compounds in drug discovery which produce
diverse therapeutically related applications in pharmacological practices. Researches in …

Green synthesis, antibacterial and antifungal evaluation of new thiazolidine-2, 4-dione derivatives: molecular dynamic simulation, POM study and identification of …

S Ahmed, AR Bhat, AK Rahiman… - Journal of …, 2024 - Taylor & Francis
In this study, a series of thiazolidine-2, 4-dione derivatives 3a–i were synthesized and
evaluated for antibacterial activity against Gram-positive and Gram-negative strains of …

Natural products-based drugs: potential therapeutics against Alzheimer's disease and other neurological disorders

M Ayaz, F Ullah, A Sadiq, MO Kim, T Ali - Frontiers in pharmacology, 2019 - frontiersin.org
Alzheimer's disease (AD) and dementia are disorders of the aging population and becoming
major health care burden worldwide due to unavailability of complete therapy. AD is the …