Brain‐derived neurotrophic factor (BDNF) is a neurotrophin, which plays an important role in
the central nervous system, and systemic or peripheral inflammatory conditions, such as …

Abstract The melanocortin-4 receptor (MC4R) is a critical regulator of energy homeostasis,
including both energy intake and energy expenditure. It mediates the actions of a number of …

Inflammation, decreased levels of circulating endothelial nitric oxide (eNO) and brain-
derived neurotrophic factor (BDNF), altered activity of hypothalamic neurotransmitters …

As the most recent melanocortin receptor (MCR) identified, melanocortin-5 receptor (MC5R)
has unique tissue expression patterns, pharmacological properties, and physiological …

G protein-coupled receptors (GPCRs) are highly conserved versatile signaling molecules
located at the plasma membrane that respond to diverse extracellular signals. They regulate …

Abstract The melanocortin-4 receptor (MC4R) is a Family AG protein-coupled receptor that
plays an essential role in regulating energy homeostasis, including both energy intake and …

G protein-coupled receptors (GPCRs), the largest family of membrane receptors in the
mammalian genomes, regulate almost all known physiological processes by transducing …

Brain derived neurotrophic factor (BDNF) is thought to play an important role in glucose
metabolism, but the exact mechanism has not been elucidated. The aim was to assess …

Major depression is one of the most prevalent mental disorders, causing significant human
suffering and socioeconomic loss. Since conventional antidepressants are not sufficiently …

Background Rare variants in melanocortin 4 receptor gene (MC4R) result in a severe form of
early-onset obesity; however, it is unclear how these variants may affect abdominal fat …