Chromatin gatekeeper and modifier CHD proteins in development, and in autism and other neurological disorders

T Muhammad, SF Pastore, K Good, J Ausió… - Psychiatric …, 2023 - journals.lww.com
Chromatin, a protein–DNA complex, is a dynamic structure that stores genetic information
within the nucleus and responds to molecular/cellular changes in its structure, providing …

Structural characterization of the RNA-binding protein SERBP1 reveals intrinsic disorder and atypical RNA binding modes

A Baudin, AK Moreno-Romero, X Xu… - Frontiers in Molecular …, 2021 - frontiersin.org
RNA binding proteins (RBPs) are essential for critical biological processes such as
translation regulation and mRNA processing, and misfunctions of these proteins are …

KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA …

J Zhou, T Wang, H Zhang, J Liu, P Wei, R Xu… - Plos …, 2024 - journals.plos.org
Ferroptosis, a defensive strategy commonly employed by the host cells to restrict pathogenic
infections, has been implicated in the development and therapeutic responses of various …

Loss of miR-26a-5p promotes proliferation, migration, and invasion in prostate cancer through negatively regulating SERBP1

K Guo, S Zheng, Y Xu, A Xu, B Chen, Y Wen - Tumor Biology, 2016 - Springer
The biological role of miR-26a involved in the carcinogenesis of prostate cancer (PC) has
been controversial. Besides, the underlying mechanism by which miR-26a plays a role in …

NEK10 interactome and depletion reveal new roles in mitochondria

A Peres de Oliveira, FL Basei, PF Slepicka… - Proteome Science, 2020 - Springer
Background Members of the family of NEK protein kinases (NIMA-related kinases) were
described to have crucial roles in regulating different aspects of the cell cycle. NEK10 was …

A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division

S Martini, K Davis, R Faraway, L Elze… - Nature …, 2021 - nature.com
The PKCε-regulated genome protective pathway provides transformed cells a failsafe to
successfully complete mitosis. Despite the necessary role for Aurora B in this programme, it …

SERBP1 affects homologous recombination-mediated DNA repair by regulation of CtIP translation during S phase

JW Ahn, S Kim, W Na, SJ Baek, JH Kim… - Nucleic acids …, 2015 - academic.oup.com
DNA double-strand breaks (DSBs) are the most severe type of DNA damage and are
primarily repaired by non-homologous end joining (NHEJ) and homologous recombination …

Complex interactomes and post-translational modifications of the regulatory proteins HABP4 and SERBP1 suggest pleiotropic cellular functions

C Colleti, TD Melo-Hanchuk… - World journal of …, 2019 - pmc.ncbi.nlm.nih.gov
The 57 kDa antigen recognized by the Ki-1 antibody, is also known as intracellular
hyaluronic acid binding protein 4 and shares 40.7% identity and 67.4% similarity with serpin …

SERBP1 affects the apoptotic level by regulating the expression and alternative splicing of cellular and metabolic process genes in HeLa cells

J Zhou, W Chen, Q He, D Chen, C Li, C Jiang, Z Ding… - PeerJ, 2022 - peerj.com
Background RNA-binding proteins (RBPs) have important roles in orchestrating
posttranscriptional regulation and modulating many tumorigenesis events. SERBP1 has …

The RNA-binding protein SERBP1 interacts selectively with the signaling protein RACK1

GB Bolger - Cellular signalling, 2017 - Elsevier
The RACK1 protein interacts with numerous proteins involved in signal transduction, the
cytoskeleton, and mRNA splicing and translation. We used the 2-hybrid system to identify …