[HTML][HTML] Digital pathology and artificial intelligence in translational medicine and clinical practice

V Baxi, R Edwards, M Montalto, S Saha - Modern Pathology, 2022 - Elsevier
Traditional pathology approaches have played an integral role in the delivery of diagnosis,
semi-quantitative or qualitative assessment of protein expression, and classification of …

Artificial intelligence to identify genetic alterations in conventional histopathology

D Cifci, S Foersch, JN Kather - The Journal of Pathology, 2022 - Wiley Online Library
Precision oncology relies on the identification of targetable molecular alterations in tumor
tissues. In many tumor types, a limited set of molecular tests is currently part of standard …

The impact of site-specific digital histology signatures on deep learning model accuracy and bias

FM Howard, J Dolezal, S Kochanny, J Schulte… - Nature …, 2021 - nature.com
Abstract The Cancer Genome Atlas (TCGA) is one of the largest biorepositories of digital
histology. Deep learning (DL) models have been trained on TCGA to predict numerous …

Deep learning-based image analysis predicts PD-L1 status from H&E-stained histopathology images in breast cancer

G Shamai, A Livne, A Polónia, E Sabo, A Cretu… - Nature …, 2022 - nature.com
Abstract Programmed death ligand-1 (PD-L1) has been recently adopted for breast cancer
as a predictive biomarker for immunotherapies. The cost, time, and variability of PD-L1 …

[HTML][HTML] The ethical, legal and social implications of using artificial intelligence systems in breast cancer care

SM Carter, W Rogers, KT Win, H Frazer, B Richards… - The Breast, 2020 - Elsevier
Breast cancer care is a leading area for development of artificial intelligence (AI), with
applications including screening and diagnosis, risk calculation, prognostication and clinical …

Determining breast cancer biomarker status and associated morphological features using deep learning

P Gamble, R Jaroensri, H Wang, F Tan… - Communications …, 2021 - nature.com
Background Breast cancer management depends on biomarkers including estrogen
receptor, progesterone receptor, and human epidermal growth factor receptor 2 …

[HTML][HTML] Artificial intelligence in digital breast pathology: techniques and applications

A Ibrahim, P Gamble, R Jaroensri, MM Abdelsamea… - The Breast, 2020 - Elsevier
Breast cancer is the most common cancer and second leading cause of cancer-related
death worldwide. The mainstay of breast cancer workup is histopathological diagnosis …

Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains

N Naik, A Madani, A Esteva, NS Keskar… - Nature …, 2020 - nature.com
For newly diagnosed breast cancer, estrogen receptor status (ERS) is a key molecular
marker used for prognosis and treatment decisions. During clinical management, ERS is …

A guide to artificial intelligence for cancer researchers

R Perez-Lopez, N Ghaffari Laleh, F Mahmood… - Nature Reviews …, 2024 - nature.com
Artificial intelligence (AI) has been commoditized. It has evolved from a specialty resource to
a readily accessible tool for cancer researchers. AI-based tools can boost research …

Spatial transcriptomics inferred from pathology whole-slide images links tumor heterogeneity to survival in breast and lung cancer

A Levy-Jurgenson, X Tekpli, VN Kristensen… - Scientific reports, 2020 - nature.com
Digital analysis of pathology whole-slide images is fast becoming a game changer in cancer
diagnosis and treatment. Specifically, deep learning methods have shown great potential to …