The mechanism of ferroptosis and its related diseases

S Feng, D Tang, Y Wang, X Li, H Bao, C Tang… - Molecular …, 2023 - Springer
Ferroptosis, a regulated form of cellular death characterized by the iron-mediated
accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of …

Ferritinophagy: research advance and clinical significance in cancers

J Wang, N Wu, M Peng, L Oyang, X Jiang, Q Peng… - Cell Death …, 2023 - nature.com
Ferritinophagy, a process involving selective autophagy of ferritin facilitated by nuclear
receptor coactivator 4 (NCOA4), entails the recognition of ferritin by NCOA4 and subsequent …

Hemochromatosis: ferroptosis, ROS, gut microbiome, and clinical challenges with alcohol as confounding variable

R Teschke - International Journal of Molecular Sciences, 2024 - mdpi.com
Hemochromatosis represents clinically one of the most important genetic storage diseases
of the liver caused by iron overload, which is to be differentiated from hepatic iron overload …

Double-layer optical fiber interferometer with bio-layer-modified reflector for label-free biosensing of inflammatory proteins

D Burnat, M Janik, N Kwietniewski, A Martychowiec… - Scientific Reports, 2024 - nature.com
This work discusses label-free biosensing application of a double-layer optical fiber
interferometer where the second layer tailors the reflection conditions at the external plain …

The impact of inflammation and acute phase activation in cancer cachexia

TP Robinson, T Hamidi, B Counts… - Frontiers in …, 2023 - frontiersin.org
The development of cachexia in the setting of cancer or other chronic diseases is a
significant detriment for patients. Cachexia is associated with a decreased ability to tolerate …

Iron as a therapeutic target in chronic liver disease

E Kouroumalis, I Tsomidis… - World Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
It was clearly realized more than 50 years ago that iron deposition in the liver may be a
critical factor in the development and progression of liver disease. The recent clarification of …

Puerarin reduces cell damage from cerebral ischemia-reperfusion by inhibiting ferroptosis

C Li, Y Liu - Biochemical and Biophysical Research …, 2024 - Elsevier
This study explores the protective effects of Puerarin, a compound derived from the
traditional Chinese herb Pueraria, against cellular damage induced by Oxygen-Glucose …

Polycystic ovary syndrome and iron overload: biochemical link and underlying mechanisms with potential novel therapeutic avenues

M Mathew, S Sivaprakasam, JL Phy… - Bioscience …, 2023 - portlandpress.com
Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder in women with
components of significant genetic predisposition and possibly multiple, but not yet clearly …

Ferritin microheterogeneity, subunit composition, functional, and physiological implications

AK Srivastava, AA Reutovich, NJ Hunter, P Arosio… - Scientific Reports, 2023 - nature.com
Ferritin is a ubiquitous intracellular iron storage protein that plays a crucial role in iron
homeostasis. Animal tissue ferritins consist of multiple isoforms (or isoferritins) with different …

Emerging insights: miRNA modulation of ferroptosis pathways in lung cancer

EGE Elsakka, HM Midan, AI Abulsoud, D Fathi… - Experimental Cell …, 2024 - Elsevier
The newly discovered programmed iron-dependent necrosis, ferroptosis, is a novel pathway
that is controlled by iron-dependent lipid peroxidation and cellular redox changes. It can be …