Hidradenitis suppurativa
R Sabat, GBE Jemec, Ł Matusiak, AB Kimball… - Nature Reviews …, 2020 - nature.com
Hidradenitis suppurativa (HS; also designated as acne inversa) is a chronic inflammatory
disorder, which affects the intertriginous skin and is associated with numerous systemic …
disorder, which affects the intertriginous skin and is associated with numerous systemic …
Pyoderma gangrenosum
E Maverakis, AV Marzano, ST Le, JP Callen… - Nature Reviews …, 2020 - nature.com
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that presents with rapidly
develo**, painful skin ulcers hallmarked by undermined borders and peripheral erythema …
develo**, painful skin ulcers hallmarked by undermined borders and peripheral erythema …
Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis
The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin,
is incompletely understood. Here we demonstrate, using a combination of single cell and …
is incompletely understood. Here we demonstrate, using a combination of single cell and …
Pathogenesis of psoriasis and development of treatment
E Ogawa, Y Sato, A Minagawa… - The Journal of …, 2018 - Wiley Online Library
The pathogenesis of psoriasis can be explained by dysregulation of immunological cell
function as well as keratinocyte proliferation/differentiation. Recently, the immunological …
function as well as keratinocyte proliferation/differentiation. Recently, the immunological …
[HTML][HTML] Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin
The skin serves as the primary interface between our body and the external environment
and acts as a barrier against entry of physical agents, chemicals, and microbes …
and acts as a barrier against entry of physical agents, chemicals, and microbes …
The interplay between keratinocytes and immune cells in the pathogenesis of psoriasis
C Albanesi, S Madonna, P Gisondi… - Frontiers in …, 2018 - frontiersin.org
Psoriasis is a chronic inflammatory skin disease resulting from genetic, epigenetic,
environmental, and lifestyle factors. To date, several immunopathogenic mechanisms of …
environmental, and lifestyle factors. To date, several immunopathogenic mechanisms of …
IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis
A Johnston, X **ng, L Wolterink, DH Barnes… - Journal of Allergy and …, 2017 - Elsevier
Background Generalized pustular psoriasis (GPP) is a rare, debilitating, and often life-
threatening inflammatory disease characterized by episodic infiltration of neutrophils into the …
threatening inflammatory disease characterized by episodic infiltration of neutrophils into the …
Aetiology and pathogenesis of hidradenitis suppurativa
K Wolk, O Join‐Lambert, R Sabat - British Journal of …, 2020 - academic.oup.com
Hidradenitis suppurativa (HS) is a chronic inflammatory disorder. Patients develop inflamed
nodules and abscesses and, at later stages of disease, epithelialized tunnels and scars in …
nodules and abscesses and, at later stages of disease, epithelialized tunnels and scars in …
Cytokines in psoriasis
J Baliwag, DH Barnes, A Johnston - Cytokine, 2015 - Elsevier
Psoriasis is a common inflammatory skin disease with an incompletely understood etiology.
The disease is characterized by red, scaly and well-demarcated skin lesions formed by the …
The disease is characterized by red, scaly and well-demarcated skin lesions formed by the …
Psoriasis: a mixed autoimmune and autoinflammatory disease
Highlights•Plaque psoriasis exhibits both autoimmune and autoinflammatory immune
responses.•The autoinflammatory loop in psoriasis is driven by IL-36 cytokine responses.• …
responses.•The autoinflammatory loop in psoriasis is driven by IL-36 cytokine responses.• …