B cells develop from hematopoietic stem cells in the bone marrow. Once generated, they
serve multiple roles in immune regulation and host defense. However, their most important …

Since the first clinical report in 2013, inhibitors of the intracellular kinase BTK (BTKi) have
profoundly altered the treatment paradigm of B cell malignancies, replacing chemotherapy …

STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a
central role in the pathophysiology of allergic inflammation. We have identified 16 patients …

Background Patients with immunocompromised disorders have mainly been excluded from
clinical trials of vaccination against COVID-19. Thus, the aim of this prospective clinical trial …

The caspase activation and recruitment domain-coiled-coil (CARD-CC) family of proteins—
CARD9, CARD10, CARD11, and CARD14—is collectively expressed across nearly all …

Introduction CARD11 is a lymphoid lineage-specific scaffold protein regulating the NF-κB
activation downstream of the antigen receptor signal pathway. Defective CARD11 function …

Myeloid leukemia associated with Down syndrome (ML-DS) has a unique molecular
landscape that differs from other subtypes of acute myeloid leukemia. ML-DS is often …

The discovery of humans with monogenic disorders has a rich history of generating new
insights into biology. Here we report the first human identified with complete deficiency of …

Caspase recruitment domain and membrane-associated guanylate kinase-like protein 3
(CARMA3) is a scaffold protein widely expressed in non-hematopoietic cells. It is encoded …

CARD11 is a multidomain scaffold protein required for normal activation of NF-κB, JNK, and
mTOR during Ag receptor signaling. Germline CARD11 mutations cause at least three types …