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Organ‐on‐chip models: implications in drug discovery and clinical applications
R Mittal, FW Woo, CS Castro, MA Cohen… - Journal of cellular …, 2019 - Wiley Online Library
Before a lead compound goes through a clinical trial, preclinical studies utilize two‐
dimensional (2D) in vitro models and animal models to study the pharmacodynamics and …
dimensional (2D) in vitro models and animal models to study the pharmacodynamics and …
How can machine learning and multiscale modeling benefit ocular drug development?
The eyes possess sophisticated physiological structures, diverse disease targets, limited
drug delivery space, distinctive barriers, and complicated biomechanical processes …
drug delivery space, distinctive barriers, and complicated biomechanical processes …
Develo** organs‐on‐chips for biomedical applications
In recent years, organs‐on‐chips have been arousing great interest for their bionic and
stable construction of crucial human organs in vitro. Compared with traditional animal …
stable construction of crucial human organs in vitro. Compared with traditional animal …
[HTML][HTML] Organoids and organ chips in ophthalmology
Recent advances have driven the development of stem cell-derived, self-organizing, three-
dimensional miniature organs, termed organoids, which mimic different eye tissues …
dimensional miniature organs, termed organoids, which mimic different eye tissues …
[HTML][HTML] Stem cell-based retina models
From the early days of cell biological research, the eye—especially the retina—has evoked
broad interest among scientists. The retina has since been thoroughly investigated and …
broad interest among scientists. The retina has since been thoroughly investigated and …
Translational nanomedicines across human reproductive organs modeling on microfluidic chips: state-of-the-art and future prospects
Forecasting the consequence of nanoparticles (NPs) and therapeutically significant
molecules before materializing for human clinical trials is a mainstay for drug delivery and …
molecules before materializing for human clinical trials is a mainstay for drug delivery and …
Recent lab‐on‐chip developments for novel drug discovery
Microelectromechanical systems (MEMS) and micro total analysis systems (μTAS)
revolutionized the biochemical and electronic industries, and this miniaturization process …
revolutionized the biochemical and electronic industries, and this miniaturization process …
[HTML][HTML] Advanced fabrication techniques of microengineered physiological systems
The field of organs-on-chips (OOCs) has experienced tremendous growth over the last
decade. However, the current main limiting factor for further growth lies in the fabrication …
decade. However, the current main limiting factor for further growth lies in the fabrication …
Organ-on-a-chip technologies that can transform ophthalmic drug discovery and disease modeling
Introduction: Disorders of the eye that lead to visual impairment are affecting millions of
people worldwide. Nevertheless, for many of these disorders, there are still no effective …
people worldwide. Nevertheless, for many of these disorders, there are still no effective …
Refinements in the use of silicone oil as an intraocular tamponade
It is over 60 years since Paul Cibis et al. reported the experimental use of liquid silicone in
the surgical management of retinal detachment. Initial experiences were complicated by …
the surgical management of retinal detachment. Initial experiences were complicated by …