How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …
preclinical models and emerging evidence in humans have established the crucial roles of …
[HTML][HTML] The lymphatic vasculature in the 21st century: novel functional roles in homeostasis and disease
Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …
Cross-tissue immune cell analysis reveals tissue-specific features in humans
Despite their crucial role in health and disease, our knowledge of immune cells within
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …
Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology
An effective tumor vaccine vector that can rapidly display neoantigens is urgently needed.
Outer membrane vesicles (OMVs) can strongly activate the innate immune system and are …
Outer membrane vesicles (OMVs) can strongly activate the innate immune system and are …
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune
responses according to peripheral cues. After four decades of research, we now know that …
responses according to peripheral cues. After four decades of research, we now know that …
Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns
MF Bachmann, GT Jennings - Nature Reviews Immunology, 2010 - nature.com
Researchers working on the development of vaccines face an inherent dilemma: to
maximize immunogenicity without compromising safety and tolerability. Early vaccines often …
maximize immunogenicity without compromising safety and tolerability. Early vaccines often …
Cancer cell membrane-coated adjuvant nanoparticles with mannose modification for effective anticancer vaccination
Tumor vaccines for cancer prevention and treatment have attracted tremendous interests in
the area of cancer immunotherapy in recent years. In this work, we present a strategy to …
the area of cancer immunotherapy in recent years. In this work, we present a strategy to …
Paradoxical roles of the immune system during cancer development
The main function of the mammalian immune system is to monitor tissue homeostasis, to
protect against invading or infectious pathogens and to eliminate damaged cells. Therefore …
protect against invading or infectious pathogens and to eliminate damaged cells. Therefore …
Taking dendritic cells into medicine
RM Steinman, J Banchereau - Nature, 2007 - nature.com
Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring about
resistance to infection and silencing or tolerance to self. In the settings of infection and …
resistance to infection and silencing or tolerance to self. In the settings of infection and …
[HTML][HTML] Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation
Naive CD4+ T cell differentiation into distinct subsets of T helper (Th) cells is a pivotal
process in the initiation of the adaptive immune response. Allergens predominantly stimulate …
process in the initiation of the adaptive immune response. Allergens predominantly stimulate …