Simple Summary Biliary tract cancers (BTCs) are rare tumours associated with poor
prognosis. In advanced-stage disease, two treatment lines are approved: gemcitabine …

Highlights•CCAs may harbor a range of genetic alterations, some of which are actionable
targets.•It is now recommented to treat patients with IDH1 and FGFR2 alterations with …

Background Cholangiocarcinoma (CCA) is a primary malignancy of the biliary tract with a
dismal prognosis. Recently, several actionable genetic aberrations were identified with …

Simple Summary Intrahepatic cholangiocarcinoma is the second most common primary liver
malignancy. Among patients with operable disease, surgical resection is the cornerstone of …

Cholangiocarcinoma is a lethal malignancy of the biliary epithelium that can arise anywhere
along the biliary tract. Surgical resection confers the greatest likelihood of long‐term …

Cancers of the digestive system are major contributors to global cancer-associated morbidity
and mortality, accounting for 35% of annual cases of cancer deaths. The etiologies …

Cholangiocarcinoma consists of a heterogeneous group of malignancies with generally
poor prognoses. Immunotherapy has emerged in the treatment landscape of many tumors …

Gallbladder (GB) carcinoma, although relatively rare, is the most common biliary tree
cholangiocarcinoma with aggressiveness and poor prognosis. It is closely associated with …

The technique 3'rapid amplification of cDNA ends (3′ RACE) allows for detection of
translocations with unknown gene partners located at the 3′ end of the chimeric transcript …

Due to the fact biliary tract cancer (BTC) is often diagnosed at an advanced stage, thus, not
eligible for resection, and due to the aggressive tumor biology, it is considered as one of the …