Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Actin plays many well-known roles in cells, and understanding any specific role is often
confounded by the overlap of multiple actin-based structures in space and time. Here, we …

Tissue homeostasis requires maintenance of functional integrity under stress. A central
source of stress is mechanical force that acts on cells, their nuclei, and chromatin, but how …

Mitochondrial division requires division of both the inner and outer mitochondrial
membranes (IMM and OMM, respectively). Interaction with endoplasmic reticulum (ER) …

Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Actin plays roles in many important cellular processes, including cell motility, organelle
movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the …

In response to different types and intensities of mechanical force, cells modulate their
physical properties and adapt their plasma membrane (PM). Caveolae are PM nano …

Myelin is essential for rapid nerve signaling and is increasingly found to play important roles
in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as …

Cells generate and sense mechanical forces that trigger biochemical signals to elicit cellular
responses that control cell fate changes. Mechanical forces also physically distort …

The mitochondrial and endoplasmic reticulum (ER) homeostasis is pivotal to the
maintenance of an array of physiological processes. The physical contact and association …