Trapped fat: Obesity pathogenesis as an intrinsic disorder in metabolic fuel partitioning
MI Friedman, TIA Sørensen, G Taubes, J Lund… - Obesity …, 2024 - Wiley Online Library
Our understanding of the pathophysiology of obesity remains at best incomplete despite a
century of research. During this time, two alternative perspectives have helped shape …
century of research. During this time, two alternative perspectives have helped shape …
Comprehensive quantification of metabolic flux during acute cold stress in mice
Cold-induced thermogenesis (CIT) is widely studied as a potential avenue to treat obesity,
but a thorough understanding of the metabolic changes driving CIT is lacking. Here, we …
but a thorough understanding of the metabolic changes driving CIT is lacking. Here, we …
Weighing in on the role of brown adipose tissue for treatment of obesity
B Prapaharan, M Lea… - Journal of Pharmacy & …, 2024 - frontierspartnerships.org
Brown adipose tissue (BAT) activation is an emerging target for obesity treatments due to its
thermogenic properties stemming from its ability to shuttle energy through uncoupling …
thermogenic properties stemming from its ability to shuttle energy through uncoupling …
Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health
Glutamine and glutamate are interconverted by several enzymes and alterations in this
metabolic cycle are linked to cardiometabolic traits. Herein, we show that obesity-associated …
metabolic cycle are linked to cardiometabolic traits. Herein, we show that obesity-associated …
Human brown fat and metabolic disease: a heated debate
RK Gupta - The Journal of Clinical Investigation, 2023 - Am Soc Clin Investig
Mammals maintain thermoregulation in the face of cold environmental temperatures by
activating bioenergetic mechanisms that increase heat production. Included in this response …
activating bioenergetic mechanisms that increase heat production. Included in this response …
BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis
ARP Verkerke, D Wang, N Yoshida, ZH Taxin, X Shi… - Cell, 2024 - cell.com
Brown adipose tissue (BAT) is best known for thermogenesis. Rodent studies demonstrated
that enhanced BAT thermogenesis is tightly associated with increased energy expenditure …
that enhanced BAT thermogenesis is tightly associated with increased energy expenditure …
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress
Brown adipose tissue (BAT) engages futile fatty acid synthesis–oxidation cycling, the
purpose of which has remained elusive. Here, we show that ATP-citrate lyase (ACLY), which …
purpose of which has remained elusive. Here, we show that ATP-citrate lyase (ACLY), which …
Monocarboxylate transporters facilitate succinate uptake into brown adipocytes
Uptake of circulating succinate by brown adipose tissue (BAT) and beige fat elevates whole-
body energy expenditure, counteracts obesity and antagonizes systemic tissue inflammation …
body energy expenditure, counteracts obesity and antagonizes systemic tissue inflammation …
IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis in brown fat
While mechanisms controlling uncoupling protein-1 (UCP1) in thermogenic adipocytes play
a pivotal role in non-shivering thermogenesis, it remains unclear whether F1Fo-ATP …
a pivotal role in non-shivering thermogenesis, it remains unclear whether F1Fo-ATP …
Extensive profiling of histidine‐containing dipeptides reveals species‐and tissue‐specific distribution and metabolism in mice, rats, and humans
Abstract Aim Histidine‐containing dipeptides (HCDs) are pleiotropic homeostatic molecules
with potent antioxidative and carbonyl quenching properties linked to various inflammatory …
with potent antioxidative and carbonyl quenching properties linked to various inflammatory …