Dysfunction of the mesocorticolimbic dopaminergic reward system is a core feature of
schizophrenia (SZ), yet its precise contributions to different stages of reward processing and …

Over the past 20 years there has been an increasing number of brain imaging studies on the
mechanisms underlying reward motivation in humans. This narrative review describes …

Abstract The National Institute of Mental Health (NIMH)'fast-fail'approach seeks to improve
too-often-misleading early-phase drug development methods by incorporating biomarker …

The cerebellum generates internal prediction models and actively compares anticipated and
actual outcomes in order to reach a desired end state. In this process, reward can serve as a …

Background While multiple studies have examined the brain functional correlates of reward,
meta-analyses have either focused on studies using the monetary incentive delay (MID) …

Both social and material rewards play a crucial role in daily life and function as strong
incentives for various goal-directed behaviors. However, it remains unclear whether the …

Choosing how much effort to expend is critical for everyday decisions. While several
neuroimaging studies have examined effort-based decision-making, results have been …

Objective Changes in reward processing are hypothesized to play a role in the onset and
maintenance of binge eating (BE). However, despite an increasing number of studies …

Social rewards or punishments motivate human learning and behaviour, and alterations in
the brain circuits involved in the processing of these stimuli have been linked with several …

Background Major depressive disorder (MDD) is the leading cause of years lived with
disability worldwide, and up to 40% of individuals with MDD do not respond to current …