Hepatocyte resident afflictions continue to affect the human population unabated. The
asialoglycoprotein receptor (ASGPR) is primarily expressed on hepatocytes and minimally …

Selective targeting of ligand-targeted liposomes containing anticancer drugs or therapeutic
genes to cell surface receptors expressed on cancer cells is a recognized strategy for …

Many serious liver diseases affecting millions of people world-wide cannot be treated
despite many efforts which warrants a search for new therapeutic strategies. Potent drugs …

This research deals with the development of asialoglycoprotein receptors (ASGPR) directed
nanoliposomes incorporating a novel BRD4 (Bromodomain-containing protein 4) protein …

Gene editing is a crucial and effective strategy to treat genetic diseases. Safe and effective
delivery vectors are specially required for efficient gene editing in vivo of CRISPR/Cas9 …

Liver cancer is currently regarded as the second leading cause of cancer-related mortality
globally and is the sixth most diagnosed malignancy. Selenium nanoparticles (SeNPs) have …

Liver is a vital organ responsible for plethora of functions including detoxification, protein
synthesis, and the production of biochemicals necessary for the sustenance of life …

The formulation of novel delivery protocols for the targeted delivery of genes into
hepatocytes by receptor mediation is important for the treatment of liver-specific disorders …

The overexpression of the human epidermal growth factor 2 (HER2/neu) oncogene is
predictive of adverse breast cancer prognosis. Silencing the HER2/neu overexpression …

Silymarin has hepatoprotective properties and is used in treatment of various liver diseases,
but its bioavailability from oral products is very poor. In order to overcome its poor oral …