The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

The thyroid hormone receptors, TRα1, TRβ1 and other subtypes, are members of the
nuclear receptor superfamily that mediate the action of thyroid hormone signaling in …

The potential estrogenic activities of perfluoroalkyl substances (PFASs) are controversial.
Here, we investigated the estrogenic/antiestrogenic activities of PFASs and explored the …

Abstract Nuclear Receptors (NRs) are multi-domain proteins, whose natural regulation
occurs via ligands for a classical, orthosteric, binding pocket and via intra-and inter-domain …

Plasticizers added to polyvinylchloride (PVC) used in medical devices can be released into
patients' biological fluids. Di-(2-ethylhexyl) phthalate (DEHP), a well-known reprotoxic and …

Thyroid hormones (TH) cross the plasma membrane with the help of transporter proteins. As
charged amino acid derivatives, TH cannot simply diffuse across a lipid bilayer membrane …

Nuclear receptors (NRs) are a family of ligand-regulated transcription factors that modulate a
wide variety of physiological functions in a ligand-dependent manner. The first NRs were …

The nuclear thyroid hormone receptors (THRs) are key mediators of thyroid hormone
function on the cellular level via modulation of gene expression. Two different genes encode …

The nuclear receptors (NRs) are an evolutionarily related family of transcription factors,
which share certain common structural characteristics and regulate the expressions of …

Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardant
chemicals that have been used in large quantities and are now detected worldwide in …