The brain is unique among organs in many respects, including its mechanisms of lipid
synthesis and energy production. The nervous system-specific metabolite N-acetylaspartate …

Metabolomics is the discipline where endogenous and exogenous metabolites are
assessed, identified and quantified in different biological samples. Metabolites are crucial …

Multiple sclerosis is a complex and heterogeneous, most likely autoimmune, demyelinating
disease of the central nervous system (CNS). Although a number of histological …

Background Multiple sclerosis is an inflammatory demyelinating disease of the central
nervous system and is the most common cause of neurologic disability in young adults …

Recent magnetic resonance (MR) studies of multiple sclerosis lesions indicate that axonal
injury is a major correlate of permanent clinical deficit. In the present study we systematically …

Multiple sclerosis is characterized morphologically by the key features demyelination,
inflammation, gliosis and axonal damage. In recent years, it has become more evident that …

Multiple sclerosis is an inflammatory demyeli‐nating disease of the central nervous system.
The hallmark of its pathology is the demyelinated plaque with reactive glial scar formation …

Axonal degeneration has been proposed as a cause of irreversible neurological disability in
multiple sclerosis (MS) patients. The purpose of this study was to quantify axonal loss in …

Aging is often accompanied by learning and memory problems, many of which resemble
deficits associated with hippocampal damage. Studies of aging in nonhuman animals have …

Abstract From 1991–2002, we treated 58 patients with multiple sclerosis (MS) using the
humanised monoclonal antibody, Campath–1H, which causes prolonged T lymphocyte …