The blood brain barrier (BBB) plays a critically important role in the regulation of central
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …

Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases.
Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently …

Antiamyloid antibodies have been used to reduce cerebral amyloid-beta (Aβ) load in
patients with Alzheimer's disease. We applied focused ultrasound with each of six monthly …

Background Low-intensity pulsed ultrasound with concomitant administration of intravenous
microbubbles (LIPU-MB) can be used to open the blood–brain barrier. We aimed to assess …

Intracerebral vector delivery in nonhuman primates has been a major challenge. We report
successful blood-brain barrier opening and focal delivery of adeno-associated virus …

Brain metastases (BMs) are an important source of morbidity and mortality in patients with
metastatic breast cancer (BC). As survival of patients with advanced BC considerably …

The blood–brain barrier (BBB) is a highly regulated physical and functional boundary that
tightly controls the transport of materials between the blood and the brain. There is an …

Background GBA1 mutation is the most common genetic risk factor for Parkinson's disease
(PD). Replacement of the lysosomal enzyme glucocerebrosidase (GCase) slows …

The blood–brain barrier (BBB) protects the brain but is also an important obstacle for the
effective delivery of therapeutics in Alzheimer's disease and other neurodegenerative …

OBJECTIVE MRI-guided low-intensity focused ultrasound (FUS) has been shown to
reversibly open the blood-brain barrier (BBB), with the potential to deliver therapeutic agents …