Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens
S Knasmüller, W Parzefall, R Sanyal, S Ecker… - Mutation Research …, 1998 - Elsevier
The human hepatoma line (Hep G2) has retained the activities of various phase I and phase
II enzymes which play a crucial role in the activation/detoxification of genotoxic …
II enzymes which play a crucial role in the activation/detoxification of genotoxic …
[HTML][HTML] γH2AX as a novel endpoint to detect DNA damage: applications for the assessment of the in vitro genotoxicity of cigarette smoke
C Garcia-Canton, A Anadón, C Meredith - Toxicology in Vitro, 2012 - Elsevier
Histone H2AX is rapidly phosphorylated to become γH2AX after exposure to DNA-damaging
agents that cause double-strand DNA breaks (DSBs). γH2AX can be detected and …
agents that cause double-strand DNA breaks (DSBs). γH2AX can be detected and …
A novel upconversion@ polydopamine core@ shell nanoparticle based aptameric biosensor for biosensing and imaging of cytochrome c inside living cells
Herein, a novel upconversion@ polydopamine core@ shell nanoparticle (termed as
UCNP@ PDA NP)-based aptameric biosensor has been fabricated for the quantitative …
UCNP@ PDA NP)-based aptameric biosensor has been fabricated for the quantitative …
Genotoxicity of dill (Anethum graveolens L.), peppermint (Mentha× piperita L.) and pine (Pinus sylvestris L.) essential oils in human lymphocytes and Drosophila …
JR Lazutka, J Mierauskien, G Slapšyt… - Food and chemical …, 2001 - Elsevier
Genotoxic properties of the essential oils extracted from dill (Anethum graveolens L.) herb
and seeds, peppermint (Mentha× piperita L.) herb and pine (Pinus sylvestris L.) needles …
and seeds, peppermint (Mentha× piperita L.) herb and pine (Pinus sylvestris L.) needles …
Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays
In the present study, DNA-damage and clastogenic or aneugenic effects of genotoxic
compounds were examined in a metabolically competent human cell line (HepG2 cells) …
compounds were examined in a metabolically competent human cell line (HepG2 cells) …
Induction of micronuclei and chromosomal aberrations by the mycotoxin patulin in mammalian cells: role of ascorbic acid as a modulator of patulin clastogenicity
I Alves, NG Oliveira, A Laires, AS Rodrigues… - Mutagenesis, 2000 - academic.oup.com
Patulin is a mycotoxin produced by several species of Penicillium, Aspergillus and
Byssochlamys. Patulin is a common contaminant of ripe apples used for the production of …
Byssochlamys. Patulin is a common contaminant of ripe apples used for the production of …
Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology
S Yoshitomi, K Ikemoto, J Takahashi, H Miki, M Namba… - Toxicology in Vitro, 2001 - Elsevier
Transformants with stable expression of a series of human cytochrome P450 (CYP)
subtypes in the human hepatic cell line, HepG2, were established. These transformants are …
subtypes in the human hepatic cell line, HepG2, were established. These transformants are …
River water genotoxicity evaluation using micronucleus assay in fish erythrocytes
CT de Lemos, PM Rödel, NR Terra… - Ecotoxicology and …, 2007 - Elsevier
The quality of Caí river water (Rio Grande do Sul State) in an area under the influence of a
petrochemical complex was studied using the micronucleus assay in erythrocytes from …
petrochemical complex was studied using the micronucleus assay in erythrocytes from …
Linalool decreases HepG2 viability by inhibiting mitochondrial complexes I and II, increasing reactive oxygen species and decreasing ATP and GSH levels
J Usta, S Kreydiyyeh, K Knio, P Barnabe… - Chemico-biological …, 2009 - Elsevier
Coriander is used as an appetizer, a common food seasoning in Mediterranean dishes, and
a remedy for many ailments. In this study we tested the biochemical effect of its essential oil …
a remedy for many ailments. In this study we tested the biochemical effect of its essential oil …
[HTML][HTML] Synergistic effects of the membrane actions of cecropin-melittin antimicrobial hybrid peptide BP100
Abstract BP100 (KKLFKKILKYL-NH 2) is a short cecropin A-melittin hybrid peptide, obtained
through a combinatorial chemistry approach, which is highly effective in inhibiting both the in …
through a combinatorial chemistry approach, which is highly effective in inhibiting both the in …