The endoplasmic reticulum (ER) is the largest single intracellular organelle, which is present
in all types of nerve cells. The ER is an interconnected, internally continuous system of …

Unfolded protein response (UPR) is an important genomic response to endoplasmic
reticulum (ER) stress. The ER chaperones, GRP78 and Gadd153, play critical roles in cell …

As the sole Ca2+ entry mechanism in a variety of non-excitable cells, store-operated calcium
(SOC) influx is important in Ca2+ signalling and many other cellular processes,,. A calcium …

Macroautophagy is an evolutionary conserved lysosomal pathway involved in the turnover
of cellular macromolecules and organelles. In spite of its essential role in tissue …

The potent sphingolipid metabolite sphingosine 1-phosphate is produced by
phosphorylation of sphingosine catalyzed by sphingosine kinase (SphK) types 1 and 2. In …

Mitochondrial cytochrome c release and inositol (1, 4, 5) trisphosphate receptor (InsP3R)-
mediated calcium release from the endoplasmic reticulum mediate apoptosis in response to …

Macroautophagy (autophagy) is a cellular catabolic process which can be described as a
self-cannibalism. It serves as an essential protective response during conditions of …

Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause late-onset Parkinson's
disease, but its physiological function has remained largely unknown. Here we report that …

The endoplasmic reticulum (ER) can elicit proapoptotic signalling that results in transmission
of Ca2+ to the mitochondria, which in turn stimulates recruitment of the fission enzyme DRP1 …

The endoplasmic reticulum (ER) is a multifunctional intracellular organelle, a component of
the cellular reticular network that allows cells to adjust to a wide variety of conditions. The …