Recurrent cancer that spreads to distant sites is the leading cause of disease-related death
among cancer patients. Cancer cells are likely to disseminate during cancer progression …

The immune system is tasked with identifying malignant cells to eliminate or prevent cancer
spread. This involves a complex orchestration of many immune cell types that together …

During tumorigenesis, tumors must evolve to evade the immune system and do so by
disrupting the genes involved in antigen processing and presentation or up-regulating …

Circulating tumor cells (CTCs) are known to be prognostic for metastatic relapse and are
detected in patients as solitary cells or cell clusters. Circulating tumor cell clusters (CTC …

Tumor dormancy, a clinically undetectable state of cancer, makes a major contribution to the
development of multidrug resistance (MDR), minimum residual disease (MRD), tumor …

Abstract Purpose: Cyclin-dependent kinase 4 (CDK4) and CDK6 inhibitors (CDK4/6i) are
highly effective against estrogen receptor–positive (ER+)/HER2− breast cancer; however …

The pattern of delayed recurrence in a subset of breast cancer patients has long been
explained by a model that incorporates a variable period of cellular or tumor mass dormancy …

A major cause of cancer recurrence following chemotherapy is cancer dormancy escape.
Taxane-based chemotherapy is standard of care in breast cancer treatment aimed at killing …

Metastasis and relapse account for the great majority of cancer-related deaths. Most
metastatic lesions are micro metastases that have the capacity to remain in a non-dividing …

Triple-negative breast cancer (TNBC) is the deadliest form of breast cancer. Unlike other
types of breast cancer that can be effectively treated by targeted therapies, no such targeted …