Off-label use of medication may be presented in these guidelines if a sufficient level of
evidence shows that it can be considered medically appropriate to a given condition and if …

Importance Tranexamic acid (TXA) is an efficient antifibrinolytic agent; however, concerns
remain about the potential adverse effects, particularly vascular occlusive events, that may …

Evaluating the performance of a clinical prediction model is crucial to establish its predictive
accuracy in the populations and settings intended for use. In this article, the first in a three …

Background Perioperative bleeding is common in patients undergoing noncardiac surgery.
Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. Methods …

Abstract These European Resuscitation Council Paediatric Life Support (PLS) guidelines,
are based on the 2020 International Consensus on Cardiopulmonary Resuscitation Science …

Background Time to treatment matters in traumatic haemorrhage but the optimal prehospital
use of blood in major trauma remains uncertain. We investigated whether use of packed red …

Background Whether prehospital administration of tranexamic acid increases the likelihood
of survival with a favorable functional outcome among patients with major trauma and …

The prevention and management of bleeding and thrombosis in patients with cirrhosis
poses several difficult clinical questions. These Clinical Practice Guidelines have been …

Background Tranexamic acid reduces surgical bleeding and decreases mortality in patients
with traumatic extracranial bleeding. Intracranial bleeding is common after traumatic brain …

Traumatic brain injury (TBI) is the most common cause of death and disability in those aged
under 40 years in the UK. Higher rates of morbidity and mortality are seen in low-income …