Animal models for diabetes: understanding the pathogenesis and finding new treatments

A King, J Bowe - Biochemical pharmacology, 2016 - Elsevier
Diabetes mellitus is a lifelong, metabolic disease that is characterised by an inability to
maintain normal glucose homeostasis. There are several different forms of diabetes …

Overnutrition, mTOR signaling, and cardiovascular diseases

G Jia, AR Aroor, LA Martinez-Lemus… - American Journal of …, 2014 - journals.physiology.org
The prevalence of obesity and associated medical disorders has increased dramatically in
the United States and throughout much of the world in the past decade. Obesity, induced by …

Involvement of essential signaling cascades and analysis of gene networks in diabesity

B Rajan, AP V, T Abunada, S Younes, S Okashah… - Genes, 2020 - mdpi.com
(1) Aims: Diabesity, defined as diabetes occurring in the context of obesity, is a serious
health problem that is associated with an increased risk of premature heart attack, stroke …

Influencing factors of thermogenic adipose tissue activity

G Zhang, Q Sun, C Liu - Frontiers in physiology, 2016 - frontiersin.org
Obesity is an escalating public health challenge and contributes tremendously to the
disease burden globally. New therapeutic strategies are required to alleviate the health …

A worm of one's own: how helminths modulate host adipose tissue function and metabolism

B Guigas, AB Molofsky - Trends in parasitology, 2015 - cell.com
Parasitic helminths have coexisted with human beings throughout time. Success in
eradicating helminths has limited helminth-induced morbidity and mortality but is also …

Association of a large panel of cytokine gene polymorphisms with complications and comorbidities in type 2 diabetes patients

KF Rodrigues, NT Pietrani, VC Sandrim… - Journal of diabetes …, 2015 - Wiley Online Library
Aims. The polymorphisms of pro‐and anti‐inflammatory cytokines may be involved in type 2
diabetes (T2D) pathogenesis and its complications. Methods. We investigated in 102 T2D …

Health impact and therapeutic manipulation of the gut microbiome

EBM Daliri, FK Ofosu, R Chelliah, BH Lee, DH Oh - High-throughput, 2020 - mdpi.com
Recent advances in microbiome studies have revealed much information about how the gut
virome, mycobiome, and gut bacteria influence health and disease. Over the years, many …

High-fat-diet induced obesity and diabetes mellitus in Th1 and Th2 biased mice strains: A brief overview and hypothesis

PS Sankaran - Chronic Diseases and Translational Medicine, 2023 - mednexus.org
Obesity and diabetes mellitus are common metabolic diseases prevalent worldwide. Mice
are commonly used to study the pathogenesis of these two conditions. Obesity and diabetes …

Interferon-gamma released from omental adipose tissue of insulin-resistant humans alters adipocyte phenotype and impairs response to insulin and adiponectin …

JM Wentworth, JG Zhang, E Bandala-Sanchez… - International Journal of …, 2017 - nature.com
Background: Inflammatory factors derived from adipose tissue have been implicated in
mediating insulin resistance in obesity. We sought to identify these using explanted human …

Gut microbiota and serum biomarker analyses in obese patients diagnosed with diabetes and hypothyroid disorder

M Tabasi, S Eybpoosh… - … syndrome and related …, 2021 - liebertpub.com
Background: Variations of serum biomarkers and bacterial diversity of the gastrointestinal
tract in obese patients with diabetes or hypothyroid are poorly understood. The aim of this …