Animal models for diabetes: understanding the pathogenesis and finding new treatments
A King, J Bowe - Biochemical pharmacology, 2016 - Elsevier
Diabetes mellitus is a lifelong, metabolic disease that is characterised by an inability to
maintain normal glucose homeostasis. There are several different forms of diabetes …
maintain normal glucose homeostasis. There are several different forms of diabetes …
Overnutrition, mTOR signaling, and cardiovascular diseases
G Jia, AR Aroor, LA Martinez-Lemus… - American Journal of …, 2014 - journals.physiology.org
The prevalence of obesity and associated medical disorders has increased dramatically in
the United States and throughout much of the world in the past decade. Obesity, induced by …
the United States and throughout much of the world in the past decade. Obesity, induced by …
Involvement of essential signaling cascades and analysis of gene networks in diabesity
B Rajan, AP V, T Abunada, S Younes, S Okashah… - Genes, 2020 - mdpi.com
(1) Aims: Diabesity, defined as diabetes occurring in the context of obesity, is a serious
health problem that is associated with an increased risk of premature heart attack, stroke …
health problem that is associated with an increased risk of premature heart attack, stroke …
Influencing factors of thermogenic adipose tissue activity
G Zhang, Q Sun, C Liu - Frontiers in physiology, 2016 - frontiersin.org
Obesity is an escalating public health challenge and contributes tremendously to the
disease burden globally. New therapeutic strategies are required to alleviate the health …
disease burden globally. New therapeutic strategies are required to alleviate the health …
A worm of one's own: how helminths modulate host adipose tissue function and metabolism
Parasitic helminths have coexisted with human beings throughout time. Success in
eradicating helminths has limited helminth-induced morbidity and mortality but is also …
eradicating helminths has limited helminth-induced morbidity and mortality but is also …
Association of a large panel of cytokine gene polymorphisms with complications and comorbidities in type 2 diabetes patients
KF Rodrigues, NT Pietrani, VC Sandrim… - Journal of diabetes …, 2015 - Wiley Online Library
Aims. The polymorphisms of pro‐and anti‐inflammatory cytokines may be involved in type 2
diabetes (T2D) pathogenesis and its complications. Methods. We investigated in 102 T2D …
diabetes (T2D) pathogenesis and its complications. Methods. We investigated in 102 T2D …
Health impact and therapeutic manipulation of the gut microbiome
Recent advances in microbiome studies have revealed much information about how the gut
virome, mycobiome, and gut bacteria influence health and disease. Over the years, many …
virome, mycobiome, and gut bacteria influence health and disease. Over the years, many …
High-fat-diet induced obesity and diabetes mellitus in Th1 and Th2 biased mice strains: A brief overview and hypothesis
PS Sankaran - Chronic Diseases and Translational Medicine, 2023 - mednexus.org
Obesity and diabetes mellitus are common metabolic diseases prevalent worldwide. Mice
are commonly used to study the pathogenesis of these two conditions. Obesity and diabetes …
are commonly used to study the pathogenesis of these two conditions. Obesity and diabetes …
Interferon-gamma released from omental adipose tissue of insulin-resistant humans alters adipocyte phenotype and impairs response to insulin and adiponectin …
JM Wentworth, JG Zhang, E Bandala-Sanchez… - International Journal of …, 2017 - nature.com
Background: Inflammatory factors derived from adipose tissue have been implicated in
mediating insulin resistance in obesity. We sought to identify these using explanted human …
mediating insulin resistance in obesity. We sought to identify these using explanted human …
Gut microbiota and serum biomarker analyses in obese patients diagnosed with diabetes and hypothyroid disorder
Background: Variations of serum biomarkers and bacterial diversity of the gastrointestinal
tract in obese patients with diabetes or hypothyroid are poorly understood. The aim of this …
tract in obese patients with diabetes or hypothyroid are poorly understood. The aim of this …