Vancomycin Resistance in Enterococcus and Staphylococcus aureus

G Li, MJ Walker, DMP De Oliveira - Microorganisms, 2022 - mdpi.com
Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus are both common
commensals and major opportunistic human pathogens. In recent decades, these bacteria …

Novel Antibody-Based Protection/Therapeutics in Staphylococcus aureus

X Chen, D Missiakas - Annual Review of Microbiology, 2024 - annualreviews.org
Staphylococcus aureus is a commensal of the skin and nares of humans as well as the
causative agent of infections associated with significant mortality. The acquisition of …

Current promising strategies against antibiotic-resistant bacterial infections

J Ye, X Chen - Antibiotics, 2022 - mdpi.com
Infections caused by antibiotic-resistant bacteria (ARB) are one of the major global health
challenges of our time. In addition to develo** new antibiotics to combat ARB, sensitizing …

The immune evasion roles of Staphylococcus aureus protein A and impact on vaccine development

A Bear, T Locke, S Rowland-Jones… - Frontiers in Cellular …, 2023 - frontiersin.org
While Staphylococcus aureus (S. aureus) bacteria are part of the human commensal flora,
opportunistic invasion following breach of the epithelial layers can lead to a wide array of …

Conserved moonlighting protein pyruvate dehydrogenase induces robust protection against Staphylococcus aureus infection

X Wang, Y Dou, J Hu, CHC Chan, R Li, L Rong… - Proceedings of the …, 2024 - pnas.org
Develo** an effective Staphylococcus aureus (S. aureus) vaccine has been a challenging
endeavor, as demonstrated by numerous failed clinical trials over the years. In this study, we …

Vaccines and monoclonal antibodies as alternative strategies to antibiotics to fight antimicrobial resistance

C La Guidara, R Adamo, C Sala, F Micoli - International Journal of …, 2024 - mdpi.com
Antimicrobial resistance (AMR) is one of the most critical threats to global public health in the
21st century, causing a large number of deaths every year in both high-income and low-and …

The endothelium at the interface between tissues and Staphylococcus aureus in the bloodstream

P Speziale, TJ Foster, CR Arciola - Clinical Microbiology Reviews, 2025 - journals.asm.org
Staphylococcus aureus is a major human pathogen. It can cause many types of infections, in
particular bacteremia, which frequently leads to infective endocarditis, osteomyelitis, sepsis …

Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models

X Chen, H Gula, T Pius, C Ou… - Proceedings of the …, 2023 - National Acad Sciences
Antibodies bind target molecules with exquisite specificity. The removal of these targets is
mediated by the effector functions of antibodies. We reported earlier that the monoclonal …

Outsmarting Pathogens with Antibody Engineering

AN Qerqez, RP Silva, JA Maynard - Annual Review of Chemical …, 2023 - annualreviews.org
There is growing interest in identifying antibodies that protect against infectious diseases,
especially for high-risk individuals and pathogens for which no vaccine is yet available …

Multi-Antigen Outer Membrane Vesicle Engineering to Develop Polyvalent Vaccines: The Staphylococcus aureus Case

E König, A Gagliardi, I Riedmiller, C Andretta… - Frontiers in …, 2021 - frontiersin.org
Modification of surface antigens and differential expression of virulence factors are frequent
strategies pathogens adopt to escape the host immune system. These escape mechanisms …