Exosomes as a new frontier of cancer liquid biopsy

D Yu, Y Li, M Wang, J Gu, W Xu, H Cai, X Fang… - Molecular cancer, 2022 - Springer
Liquid biopsy, characterized by minimally invasive detection through biofluids such as
blood, saliva, and urine, has emerged as a revolutionary strategy for cancer diagnosis and …

A review of exosomal isolation methods: is size exclusion chromatography the best option?

K Sidhom, PO Obi, A Saleem - International journal of molecular sciences, 2020 - mdpi.com
Extracellular vesicles (EVs) are membranous vesicles secreted by both prokaryotic and
eukaryotic cells and play a vital role in intercellular communication. EVs are classified into …

A one-pot isothermal Cas12-based assay for the sensitive detection of microRNAs

H Yan, Y Wen, Z Tian, N Hart, S Han… - Nature Biomedical …, 2023 - nature.com
The use of microRNAs as clinical cancer biomarkers is hindered by the absence of accurate,
fast and inexpensive assays for their detection in biofluids. Here we report a one-step and …

Metal–organic framework-functionalized paper-based electrochemical biosensor for ultrasensitive exosome assay

X Liu, X Gao, L Yang, Y Zhao, F Li - Analytical chemistry, 2021 - ACS Publications
The exosome has emerged as a promising noninvasive biomarker for the early diagnosis of
cancer. Therefore, it is highly desirable to develop simple, inexpensive, and user-friendly …

[HTML][HTML] Progress, opportunity, and perspective on exosome isolation-efforts for efficient exosome-based theranostics

D Yang, W Zhang, H Zhang, F Zhang, L Chen, L Ma… - Theranostics, 2020 - ncbi.nlm.nih.gov
Exosomes are small extracellular vesicles with diameters of 30-150 nm. In both
physiological and pathological conditions, nearly all types of cells can release exosomes …

Clinical application and detection techniques of liquid biopsy in gastric cancer

S Ma, M Zhou, Y Xu, X Gu, M Zou, G Abudushalamu… - Molecular Cancer, 2023 - Springer
Gastric cancer (GC) is one of the most common tumors worldwide and the leading cause of
tumor-related mortality. Endoscopy and serological tumor marker testing are currently the …

Microfluidic strategies for the isolation and profiling of exosomes

J Bai, X Wei, X Zhang, C Wu, Z Wang, M Chen… - TrAC Trends in …, 2023 - Elsevier
Exosomes are nanoscale extracellular vesicles carrying various cargos, which play a
significant rule in intercellular communication, disease diagnosis and treatment …

Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip

P Zhang, X Zhou, M He, Y Shang, AL Tetlow… - Nature biomedical …, 2019 - nature.com
The performance of current microfluidic methods for exosome detection is constrained by
boundary conditions, as well as fundamental limits to microscale mass transfer and …

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

JC Contreras-Naranjo, HJ Wu, VM Ugaz - Lab on a Chip, 2017 - pubs.rsc.org
Exosomes, the smallest sized extracellular vesicles (∽ 30–150 nm) packaged with lipids,
proteins, functional messenger RNAs and microRNAs, and double-stranded DNA from their …

Towards microfluidic-based exosome isolation and detection for tumor therapy

J Wang, P Ma, DH Kim, BF Liu, U Demirci - Nano Today, 2021 - Elsevier
Exosomes are a class of cell-secreted, nano-sized extracellular vesicles with a bilayer
membrane structure of 30–150 nm in diameter. Their discovery and application have …