The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to
inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial …

Simple Summary Patients with advanced melanoma are often treated with v-raf murine
sarcoma viral oncogene homolog B1 (BRAF) inhibitors. Although these agents prolong life …

The poor prognosis of pancreatic cancer is primarily due to the development of resistance to
therapies, including gemcitabine. The long noncoding RNA PVT1 (lncRNA PVT1) has been …

ABSTRACT Eukaryotic Translation Initiation Factor 5A (EIF5A) is a translation factor
regulated by hypusination, a unique posttranslational modification catalyzed by …

Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, with 20%
of patients presenting with metastatic disease at diagnosis. TGF-β signaling plays a crucial …

Cancer is a complex disease and cancer cells typically harbor multiple genetic and
epigenetic alterations. Large-scale sequencing of patient-derived cancer samples has …

Castration‐resistant prostate cancer (CRPC) is the latest stage of PCa, and there is almost
no effective treatment available for the patients with CRPC when next‐generation androgen …

Malignant melanoma is the most lethal type of skin cancer with high rates of mortality.
Although current treatment options provide a short-clinical benefit, acquired-drug resistance …

Histone modifications, as key chromatin regulators, play a pivotal role in the pathogenesis of
several diseases, such as cancer. Acetylation, and more specifically lysine acetylation, is a …

Ovarian cancer is the leading cause of gynecological malignancy-related deaths. Current
therapies for ovarian cancer do not provide meaningful and sustainable clinical benefits …